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Position: Home > Articles > Study on Preparation of Silymarin Solid Lipid Nanoparicles and in vitro Release Northern Horticulture 2012 (19) 175-178

水飞蓟素固体脂质纳米粒的制备及体外释放研究

作  者:
于莲;刘思佳;杜妍;平洋;胡艳秋;马丽娜
单  位:
佳木斯大学药学院黑龙江省高校重点实验室
关键词:
水飞蓟素;固体脂质纳米粒;乳化-超声分散法
摘  要:
以单硬脂酸甘油酯为脂质材料,豆磷脂与泊洛沙姆188为乳化剂,水飞蓟素为试验药材,采用乳化-超声分散法制备SM-SLN胶体溶液,对其粒径、形态、包封率和载药量及体外释放进行研究,并对其稳定性进行研究。结果表明:所制得的纳米粒外观形态圆整,平均粒径为150.6nm,平均包封率为85.3%。乳化-超声分散法适用于SM-SLN的制备,其制剂包封率高,粒度分布较均匀,具有较好的稳定性。
译  名:
Study on Preparation of Silymarin Solid Lipid Nanoparicles and in vitro Release
作  者:
YU Lian,LIU Si-jia,DU Yan,PING Yang,HU Yan-qiu,MA Li-na(Heilongjiang Key Lab of University,College of Pharmaceutical,Jiamusi University,Jiamusi,Heilongjiang 154007)
关键词:
silymarin;solid lipid nanoparticles;emulsification ultrasonic disp ersionmethod
摘  要:
Taking monostearin lipid as material,soybean lecithin and poloxamer 188as emulsifier,silymarin as a model drug,SM-SLN were prepared by the emulsification ultrasonic dispersion method.The particle size,morphology,encapsulation efficiency,drug loading,in vitro release and stability were studied.The results showed that morphology of SM-SLN was round and smooth,and the average particle size was 150.6nm and encapsulation efficiency 85.3%.Emulsification ultrasonic dispersion method was suitable for SM-SLN preparation,with high encapsulation efficiency,uniform particle size distribution and better stability.

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