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当前位置: 首页 > 文章 > 谷物胚乳性状QTL区间作图的贝叶斯方法 扬州大学学报(农业与生命科学版) 2008,29 (3) 12-17
Position: Home > Articles > Bayesian method for mapping QTL controlling endosperm traits in cereals Journal of Yangzhou University(Agricultural and Life Science Edition) 2008,29 (3) 12-17

谷物胚乳性状QTL区间作图的贝叶斯方法

作  者：
王亚民;孙长森;汤在祥;胡治球;徐辰武
单  位：
扬州大学;台州学院
关键词：
数量性状基因座位;贝叶斯统计;胚乳性状;MCMC算法;Gibbs抽样;Metropolis-Hastings算法
摘  要：
将贝叶斯统计原理和胚乳性状的数量遗传模型相结合,以分离群体中各植株的分子标记基因型以及植株上若干粒种子胚乳性状的单粒观测值为数据模式,提出胚乳性状QTL区间作图的贝叶斯方法。该方法通过Gibbs以及Metropolis-Hastings抽样实现的马尔科夫链蒙特卡罗(MCMC)算法获得QTL效应和位置的估计。方法的有效性用染色体水平和基因组水平2套模拟方案进行验证,结果表明:贝叶斯方法能够准确地估计胚乳性状QTL的位置和效应,并同时区分2种显性效应。
译  名：
Bayesian method for mapping QTL controlling endosperm traits in cereals
作  者：
WANG Ya-min1,2,SUN Chang-sen3,TANG Zai-xiang1,HU Zhi-qiu1,XU Chen-wu1 (1.Key Lab of Crop Gen and Phys of Jiangsu Prov,Key Lab of Plant Funct Genomics of MOE,Yangzhou Univ,Yangzhou 225009,China;2.Bas Courses of Lianyungang Tech Coll,Lianyungang 222006,China;3.Sch of Life Sci,Taizhou Univ,Linhai 317000,China)
关键词：
quantitative trait loci;Bayesian statistics;endosperm traits;MCMC;Gibbs sampling;Metropolis-Hastings algorithm
摘  要：
Endosperm traits refer to those characters that determined the grain quality in cereals.The genetic study of endosperm traits plays a fundamental and vital role in improving grain quality.Based on Bayesian statistics and quantitative genetic model of triploid endosperm traits,we proposed a Bayesian method for mapping QTL underlying endosperm traits,which used the DNA molecular marker genotypes of each plant in segregation population and the single endosperm observation of a few endosperms of each plant as data set to analyze endosperm QTL.The Bayesian estimates of QTL position and effects were obtained by Markov chain Monte Carlo(MCMC) algorithm implementing via Gibbs and Metropolis-Hastings sampling.The validation of the statistical procedure was verified through both chromosome level and genome level simulation studies.The results showed that the proposed Bayesian method can estimate the QTL position and effects exactly and distinguish the two dominance effects.

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