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当前位置: 首页 > 文章 > 水貂毛皮成熟期皮肤中EGF、IGF-Ⅰ及IGF-ⅠR基因的表达 中国畜牧兽医 2014,41 (7) 59-63
Position: Home > Articles > Expression of EGF,IGF-Ⅰand IGF-ⅠR Gene in Mink's Skin and Hair Follicles of Pelting Period China Animal Husbandry & Veterinary Medicine 2014,41 (7) 59-63

水貂毛皮成熟期皮肤中EGF、IGF-Ⅰ及IGF-ⅠR基因的表达

作  者：
张海华;张铁涛;宋兴超;常忠娟;赵靖波;周宁;李光玉
单  位：
中国农业科学院特产研究所
关键词：
水貂;毛囊;表皮生长因子;胰岛素样生长因子-Ⅰ;胰岛素样生长因子-Ⅰ受体
摘  要：
为探讨水貂皮肤和毛囊发育机理,试验运用组织学和免疫组化方法对水貂毛皮成熟期皮肤及毛囊中表皮生长因子(epidermal growth factor,EGF)和胰岛素样生长因子-Ⅰ(insulin-like growth factor-Ⅰ,IGF-Ⅰ)及其受体(insulin-like growth factor-Ⅰreceptor,IGF-ⅠR)进行了研究。结果表明,水貂皮肤表皮细胞和毛囊外根鞘细胞中都有IGF-Ⅰ、IGF-ⅠR和EGF基因的强阳性表达,3种基因主要分布于细胞质中,细胞核呈空泡状未见到阳性染色,呈苏木精复染的蓝色,皱褶区域和表皮下胶原结缔组织出现了阳性染色为非特异性阳性结果。IGF-Ⅰ、IGF-ⅠR和EGF基因在水貂皮肤表皮和毛囊外根鞘细胞中广泛表达,直接参与调控皮肤和毛囊的发育。表明EGF、IGF-Ⅰ和IGF-ⅠR基因在水貂皮肤及其衍生结构的发育中发挥着重要作用。
译  名：
Expression of EGF,IGF-Ⅰand IGF-ⅠR Gene in Mink's Skin and Hair Follicles of Pelting Period
作  者：
ZHANG Hai-hua;ZHANG Tie-tao;SONG Xing-chao;CHANG Zhong-juan;ZHAO Jing-bo;ZHOU Ning;LI Guang-yu;State Key Laboratory for Molecular Biology of Special Economic Animals,Institute of Special Animal and Plant Sciences,Chinese Academy of Agriculture Sciences;Agriculture College,Yanbian University;
关键词：
mink;;hair follicle;;EGF;;IGF-Ⅰ;;IGF-ⅠR
摘  要：
In order to study the mechanism of the development of skin and hair follicle of mink,distribution of epidermal growth factor(EGF),insulin-like growth factorⅠ(IGF-Ⅰ)and its receptor(IGF-Ⅰ R)in mink's skin and hair follicles of pelting period were studied with histological methods and immunohistochemistry.The results showed that there was a strong positive expression of IGF-Ⅰ,IGF-ⅠRand EGFgene in mink's skin epidermal cells and outer root sheath cells,these three genes were mainly distributed in the nucleus of cells,the positive reaction staining was not observed in vacuole,with hematoxylin counterstained blue,collagenous connective tissue and epidermis fold area under the positive staining was positive result of nonspecific.Widespread expression of IGF-Ⅰ,IGF-ⅠRand EGFgene in the epidermis and hair follicle outer root sheath cells of mink skin,directly involved in the regulation of skin and hair follicle development.So EGF,IGF-Ⅰ and IGF-Ⅰ Rgene plays an important role in mink skin and its derivatives development.

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