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当前位置: 首页 > 文章 > 土霉素固体脂质纳米粒的制备及其药剂学性质 中国兽医科学 2013 (5) 545-550
Position: Home > Articles > Preparation and pharmaceutical characterization of oxytetracycline solid lipid nanoparticles Chinese Veterinary Science 2013 (5) 545-550

土霉素固体脂质纳米粒的制备及其药剂学性质

作  者：
符华林;周凤;张伟;唐文;卢朝成
单  位：
动物疫病与人类健康四川省重点实验室;四川农业大学动物医学院;四川农业大学动物医学院动物疫病与人类健康四川省重点实验室;四川农业大学动物科技学院
关键词：
土霉素;固体脂质纳米粒;乳化蒸发-低温固化法;体外释药
摘  要：
为提高土霉素的稳定性,延长其作用时间,提高药物疗效,以单硬脂酸甘油酯为载体材料,采用乳化蒸发-低温固化法制备土霉素固体脂质纳米粒并对其形态、粒径、Zeta电位、包封率、稳定性和体外释药特性等进行研究。结果显示,所制备的土霉素固体脂质纳米粒外观形态圆整,分散指数为0.512,平均粒径为345.8nm,Zeta电位为-34.7mV,平均包封率为51.25%,载药量为102.5mg/g,4℃放置1个月,包封率、载药量无显著变化。药物的体外释药试验表明制备的纳米粒具有显著缓释作用。结果表明,制备的土霉素固体脂质纳米粒粒径分布范围窄,稳定性较好,对土霉素的释放具有明显的缓释效应。
译  名：
Preparation and pharmaceutical characterization of oxytetracycline solid lipid nanoparticles
作  者：
FU Hua-lin1,ZHOU Feng1,ZHANG Wei1,TANG Wen1,LU Chao-cheng1,HU Li-gui2, HU Jun1,FU Qiang 1,DENG Feng-ying1(1.Key Laboratory of Animal Disease and Human Health of Sichuan Province/College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China;2.Sichuan Jinruike Animal Pharmaceutical Co.,Ltd., Zigong 643010,China)
关键词：
oxytetracycline;solid lipid nanoparticle;emulsification evaporation-solidification at low temperature;release in vitro
摘  要：
To improve the stability,prolong the action time and improve efficacy of oxytetracycline,oxytetracycline solid lipid nanoparticles were prepared by emulsification evaporation-solidification at low temperature with glycerin monostearate.The morphology,particle size,Zeta potentials,entrapment efficiency and release behavior in vitro were investigated.In result,the obtained oxytetracycline solid lipid nanoparticles were round with a mean diameter of 345.8 nm,dispersion index of 0.512,and Zeta potential of-34.7 mV.The entrapment efficiency and drug-loading rate were 51.25% and 102.5 mg/g respectively.There were no obvious changes in entrapment efficiency and loaded drug at 4 ℃ within one month.The release behavior in vitro of oxytetracycline from solid lipid nanoparticles showed an obvious sustained release effect.The results showed that the oxytetracycline solid lipid nanoparticles had a narrow size distribution and good stability,which can sustain the release of oxytetracycline.

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