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当前位置: 首页 > 文章 > 紫海胆肠道真菌Aspergillus sp.HDf2次生代谢产物抗生物污损活性的研究 安徽农业科学 2014 (25) 22-23
Position: Home > Articles > Antifouling Secondary Metabolites from Sea Urchin-Associated Fungus Aspergillus sp. HDf2 Journal of Anhui Agricultural Sciences 2014 (25) 22-23

紫海胆肠道真菌Aspergillus sp.HDf2次生代谢产物抗生物污损活性的研究

作  者：
王蓉;何华;詹夏菲;何晓娜;周文佳;郭志凯
单  位：
海南省海洋与渔业科学院;中国热带农业科学院热带生物技术研究所
关键词：
曲霉菌;海洋真菌;次生代谢产物;抗污损;藤壶
摘  要：
[目的]对紫海胆肠道曲霉菌Aspergillus sp.HDf2的次生代谢产物进行抗海洋生物污损活性研究。[方法]采用摇瓶液体发酵,运用柱层析等方法,从发酵液中分离、纯化获得4个γ-丁烯酸内酯类单体化合物(-)-spiculisporic acid、spiculisporic acids B–D和1个secospiculisporic acid B,并且对其进行了抗藤壶幼虫附着活性测试。[结果]化合物spiculisporic acid B和secospiculisporic acid B在浓度为25 mg/L时均具有抗藤壶幼虫附着活性,其中化合物secospiculisporic acid B活性最强,其他化合物无活性。[结论]该研究首次报道它具有抗生物污损活性。
译  名：
Antifouling Secondary Metabolites from Sea Urchin-Associated Fungus Aspergillus sp. HDf2
作  者：
WANG Rong;GUO Zhi-kai;Hainan Academy of Ocean and Fisheries Sciences;Key Laboratory of Biology and Genetic Resources of Tropical Crops,Ministry of Agriculture,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences;
关键词：
Aspergillus sp.;;Marine fungus;;Secondary metabolites;;Antifouling;;Balanus amphitrite
摘  要：
[Objective]Antifouling activity of the secondary metabolites from the sea urchin( Anthocidaris crassispina) associated fungus Aspergillus sp. HDf2 was investigated. [Method] Four γ-butenolide derivatives,including(-)- spiculisporic acid,spiculisporic acids B –D,and one secospiculisporic acid B,were isolated from the filtrate of the fermented culture broth by chromatographic methods. Their anti-larval settlement activity against barnacle Balanus amphitrite were tested. [Result]Only two compounds,spiculisporic acid B and secospiculisporic acid B,were active against the larval settlement of Balanus amphitrite under 25 mg /L,in which secospiculisporic acid B showed the strongest activity. [Conclusion]The antifouling acitivity of these compounds were reported here for the first time.

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