当前位置: 首页 > 文章 > 芹菜素对LPS诱导小鼠急性肺损伤的保护作用 安徽农业科学 2015 (35) 187-189
Position: Home > Articles > The Protective Effects of Apigenin on LPS-induced Acute Lung Injury in Mice Journal of Anhui Agricultural Sciences 2015 (35) 187-189

芹菜素对LPS诱导小鼠急性肺损伤的保护作用

作  者:
王玉明;杨正涛;张乃生
单  位:
吉林大学动物医学学院
关键词:
LPS;急性肺损伤;芹菜素;NF-κB
摘  要:
[目的]揭示芹菜素的抗炎作用机制。[方法]通过建立小鼠模型,研究芹菜素对LPS诱导急性肺损伤的保护作用。[结果]芹菜素可以降低LPS诱导的肺组织损伤和肺组织MPO活性。与LPS组相比,芹菜素治疗组可以显著降低肺泡盥洗液中TNF-α、IL-1β、IL-6的表达水平,并抑制NF-κB信号通路的激活。[结论]芹菜素可以通过抑制NF-κB的激活并降低炎性细胞因子的水平,从而对小鼠急性肺损伤产生抗炎保护作用。
译  名:
The Protective Effects of Apigenin on LPS-induced Acute Lung Injury in Mice
作  者:
WANG Yu-ming;YANG Zheng-tao;ZHANG Nai-sheng;College of Veterinary Medicine,Jilin University;
关键词:
LPS;;Acute lung injury;;Apigenin;;NF-κB
摘  要:
[Objective] To reveal the anti-inflammation mechanism of apigenin. [Method] The protective effects of apigenin on LPS-induced acute lung injury were studied by establishing mice model. [Result] Apigenin could decrease the injury of lung tissues induced by LPS and MPO activity of lung tissues. Compared with LPS group,the expression levels of TNF-α,IL-6 and IL-1β in BALF were significantly decreased and the activation of NF-κB signal pathway was inhibited in apigenin group. [Conclusion] Apigenin can inhibit LPS-induced ALI in mice by inhibiting the activation of NF-κB signaling pathway and reducing the levels of inflammatory cytokines.

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