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当前位置: 首页 > 文章 > 饲喂频率对哺乳仔猪生长性能和骨骼肌蛋白质合成的影响 动物营养学报 2019 (7) 3049-3057
Position: Home > Articles > 饲喂频率对哺乳仔猪生长性能和骨骼肌蛋白质合成的影响 Chinese Journal of Animal Nutrition 2019 (7) 3049-3057

饲喂频率对哺乳仔猪生长性能和骨骼肌蛋白质合成的影响

作  者：
刘静波;曹山川;杨勇;张宏福
单  位：
西南科技大学生命科学与工程学院
关键词：
饲喂频率;生长性能;骨骼肌;蛋白质合成;仔猪
摘  要：
本试验旨在比较饲喂频率对哺乳仔猪生长性能、胴体组成和骨骼肌蛋白质合成相关基因表达的影响.试验选用来自于4头母猪的16头4日龄的"杜*长*大"仔猪,按体重和性别配对成8对,每对仔猪随机分配到每天饲喂6次组(M6组)和每天饲喂12次组(M12组),每组8头猪,每个配对内仔猪采食量保持一致,人工乳饲喂21 d.结果表明:1)与M12组相比,M6组仔猪的末重,第2周、第3周和全期的平均日增重显著提高(P<0.05),第2周、第3周和全期的料重比显著降低(P<0.05).2)与M12组相比,M6组仔猪胴体瘦肉率、背最长肌重和半腱肌重显著提高(P<0.05).3)与M12组相比,M6组仔猪背最长肌胰岛素样生长因子1(IGF1)基因表达量有提高的趋势(P=0. 05);与M12组相比,仔猪背最长肌胰岛素样生长因子1受体(IGF1R)、哺乳动物雷帕霉素靶蛋白(mTOR)、真核细胞翻译起始因子4E(EIF4E)和核糖体蛋白S6(RPS6)的mRNA表达量显著提高(P<0.05),ⅡB型活化素受体(ACVR2B)和Ⅰ型活化素受体样激酶5(ALK5)的mRNA表达量显著降低(P<0.05);与M12组相比,M6组仔猪背最长肌肌肉生长抑素(MSTN) mRNA表达量没有显著变化(P>0.05).综上所述,在本试验条件下,降低饲喂频率可促进胴体瘦肉沉积和骨骼肌生长,主要通过上调IGF1-IGF1R-mTOR通途路下调M STN受体表达来实现.
作  者：
LIU Jingbo;CAO Shanchuan;YANG Yong;ZHANG Hongfu;School of Life Science and Engineering,Southwest University of Science and Technology;State Key Laboratory of Animal Nutrition,Institute of Animal Sciences,Chinese Academy of Agricultural Sciences;
单  位：
LIU Jingbo%CAO Shanchuan%YANG Yong%ZHANG Hongfu%School of Life Science and Engineering,Southwest University of Science and Technology%State Key Laboratory of Animal Nutrition,Institute of Animal Sciences,Chinese Academy of Agricultural Sciences
关键词：
meal frequency;;growth performance;;skeletal muscle;;protein synthesis;;piglets
摘  要：
The present study was conducted to determine the effects of meal frequency on growth performance,carcass composition and muscular protein synthesis-related genes expression in suckling piglets. Sixteen piglets of a crossbred genotype [Duroc×( Landrace×Large White) ]were obtained from 4 litters in 4 successive replicates and grouped into 8 pairs according to sex and body weight. At 4 days of age,piglets within each pair were offered the same amount of feed allowance either in 6( M6 group,n = 8) or 12( M12 group,n = 8)meals per day during a 3-week interventional period. The results showed as follows: 1) compared with M12 group,the final body weight and average daily body weight at week 2,week 3 and during the whole trial in M6 group significantly increased( P<0.05),and the feed/gain at week 2,week 3 and during the whole trial significantly decreased( P<0.05). 2) Compared with M12 group,the carcass lean percentage and weight of longissimus muscle and semitendinosus muscle in M6 group significantly increased( P < 0. 05). 3) Compared with M12 group,the mRNA expression of insulin-like growth factor 1( IG F1 R) in M6 group had an increasing trend( P = 0.05); compared with M12 group,the mRNA expression of insulin-like growth factor 1 receptor( IG F1 R),mammalian target of rapamcin( mTOR),eukaryotic cells translate initiation factor 4 E( EIF4 E)and ribosomal protein S6( RPS6) in M6 group significantly increased( P < 0.05),and the mRNA expression of Ⅱ type B activated receptor( ACVR2 B) and type Ⅰ activated kinase receptor( ALK5) in M6 group significantly decreased( P<0.05); compared with M12 group,the mRNA expression of myostatin( MSTN) in M6 group had no significant change( P>0.05). Collectively,reduced meal frequency results in accelerated carcass lean deposition and muscle hypotrophy,which may be mediated by activated IGF1-IGF1 R-mTOR pathway and down-regulated expression of MSTN receptors.[Chinese Journal of Animal Nutrition,2019,31(7):3049-3057]

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