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Position: Home > Articles > Development of Regulation Factor of Type Ⅲ Secretion Systems in Enterohaemorrhagic Escherichia coli China Animal Husbandry & Veterinary Medicine 2012,39 (6) 161-164

肠出血性大肠杆菌Ⅲ型分泌系统调控因素的研究进展

作  者:
魏波;刘明强;呼和巴特尔
单  位:
内蒙古农业大学兽医学院
关键词:
肠出血性大肠杆菌;Ⅲ型分泌系统;效应蛋白
摘  要:
Ⅲ型分泌系统(TyprⅢsecretion system,T3SS)是一种将细菌蛋白通过膜屏障注入宿主细胞的装置,Ⅲ型分泌系统(T3SS)是肠出血性大肠杆菌定植反刍动物储存宿主所必需的,也是引起人致病的重要原因之一。E.coli注射蛋白质进入上皮细胞使得细菌可以黏附并且促使其长时间定植在动物体内。在此,对关于EHECⅢ型分泌系统调控的研究近况、效应蛋白表达的共调控进行了综述。
译  名:
Development of Regulation Factor of Type Ⅲ Secretion Systems in Enterohaemorrhagic Escherichia coli
作  者:
WEI Bo 1,2,LIU Ming-qiang 1,HUHE Baterer 1(1.College of Animal Science and Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;2.Institute of Biotechnology,Academy of Military Medical Sciences of PLA,Beijing 100071,China)
关键词:
enterohaemorrhagic Escherichia coli;typeⅢsecretion systems;effector protein
摘  要:
TypeⅢsecretion systems(T3SS)enable the injection of bacterial proteins through membrane barriers into host cells.This system is required for colonization of their ruminant reservoir hosts by enterohaemorrhagic Escherichia coli(EHEC)and might also be important for the etiology of disease in the incidental human host.T3SS of E.coli inject a cocktail of proteins into epithelial cells that enable bacterial attachment and promotes longer-term colonization in the animal.Here,we review recent progress in our understanding of the regulation of T3SS in EHEC,focusing on the induction and assembly of the T3SS,and the co-ordination of effector protein expression.

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