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当前位置: 首页 > 文章 > 昆虫免疫识别与病原物免疫逃避机理研究进展 昆虫学报 2009,52 (5) 97-105
Position: Home > Articles > Advances in the mechanisms of insect immune recognition and pathogen immune escape Acta Entomologica Sinica 2009,52 (5) 97-105

昆虫免疫识别与病原物免疫逃避机理研究进展

作  者：
宁媛媛;尤民生;王成树
单  位：
中国科学院上海生命科学研究院植物生理生态研究所;福建农林大学应用生态研究所
关键词：
天然免疫;模式识别蛋白;病原相关分子模式;昆虫病原物;免疫逃避
摘  要：
昆虫在长期进化过程中形成复杂的天然免疫系统,病原识别是启动下游免疫反应的第一步,这一过程主要是由不同的模式识别蛋白来完成的。目前发现并鉴定的昆虫模式识别蛋白主要包括肽聚糖识别蛋白、类免疫球蛋白、β-1,3-葡聚糖结合蛋白、C型凝集素及具多功能的载脂蛋白等,不同的蛋白种类具有不同的结构、功能及识别对象。与昆虫免疫识别相对应的是,不同昆虫病原物在进化过程中发展出不同策略的免疫逃避能力,以战胜宿主免疫而致病或最终杀死昆虫。本文就昆虫免疫过程中不同模式识别蛋白的结合对象、结构与功能,以及逐渐兴起的病原物通过分子伪装等进行免疫逃避的研究进展进行了综述。并在此基础上,作者就昆虫免疫与昆虫病理研究的发展方向进行了展望,认为只有当两方面研究相结合时,才能更好地揭示昆虫宿主与病原物之间免疫与抗免疫的动态相互作用过程。
译  名：
Advances in the mechanisms of insect immune recognition and pathogen immune escape
作  者：
NING Yuan-Yuan1,2,YOU Min-Sheng1,WANG Cheng-Shu2,(1.Institute of Applied Ecology,Fujian Agriculture and Forestry University,Fuzhou 350002,China;2.Institute of Plant Physiology and Ecology,Shanghai Institute for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China)
关键词：
Insect innate immunity;pattern recognition protein;pathogen associated molecular pattern;insect pathogen;immune escape
摘  要：
The complex of insect innate immunity is evolved in a long-term for self-defense.Pathogen recognition mediated by different pattern recognition proteins(PRPs)plays a vital role in the first step of activating the immune responses.To date,different PRPs,including peptidoglycan recognition proteins(PGRPs),immunoglobulin,β-1,3-gulcans binding proteins(βGBPs),C-type lectins and multi-functional apolipoproteins,as well as their functions in the process of recognizing molecular patterns of various insect pathogens,have been identified.To counteract host recognition,however,insect pathogens also have evolved strategies of camouflage and masking to invade insect immune responses and develop diseases or eventually kill the insect hosts.This article mainly dealt with recent advances in the mechanisms of insect immune recognition and immune escape.The former includes the binding targets,protein structures and functions of different PRPs,and the latter mainly focuses on the anti-immune strategies developed through different pathogens.Future studies on insect immunology and the mechanisms of microbial pathogenesis are discussed in some detail.Most importantly,only when the studies on immunity and pathology are well combined,can the dynamic molecular interactions between insect hosts and pathogens be properly understood.

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