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当前位置: 首页 > 文章 > 铜对生长猪肝中IGF-Ⅰ基因mRNA表达的影响 中国兽医科学 2006,36 (6) 497-501
Position: Home > Articles > Effect of copper on insulin-like growth factor and gene expression of IGF- I mRNA in liver of growing pigs Chinese Veterinary Science 2006,36 (6) 497-501

铜对生长猪肝中IGF-Ⅰ基因mRNA表达的影响

作  者：
郑鑫;刘国文;杨连玉;李家奎;夏清娟;郝德威;王哲
单  位：
华中农业大学动物科技学院;吉林农业大学动物科技学院;内蒙古民族大学动物科技学院;吉林农业大学动物科技学院 吉林长春130118;吉林大学畜牧兽医学院
关键词：
铜;猪;肝;类胰岛素生长因子;基因表达
摘  要：
采用生长试验、免疫放射分析和定量PCR方法,观察了生长猪血液中类胰岛素生长因子(IGF-I)及其结合蛋白(IGFBP3)数量的变化和IGF-I基因在肝中表达量的变化。结果显示, 每1 kg饲料中添加125-250 mg铜,能够上调IGF-I基因的表达量,显著提高猪的平均日增重,促进生长猪循环血液中IGF-I浓度的增加。试验结果证实,铜是通过促进生长激素-胰岛素样生长因子轴相关因子的合成和分泌来发挥促生长作用的。
译  名：
Effect of copper on insulin-like growth factor and gene expression of IGF- I mRNA in liver of growing pigs
作  者：
ZHENG Xin,LIU Guo-wen,YANG Lian-yu,LI Jia-kui, XIA Qing-juan,HAO De-wei,WANG Zhe (College of Animal Science and Veterinary Medicine,Jilin University , Changchun 130062,China; College of Animal Science and Technology ,Jilin Agricultural University ,Changchun 130118,China; College of Animal Science and Technology,Nei Monggol University for Nationalities,Tongliao 028042,China; College of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070, China)
关键词：
copper;porcine;liver; insulin-like growth factor;gene expression
摘  要：
The experiment was conducted in order to explore the effect of copper on growth correlation factor from the level of integer and gene expression, such as porcine liver IGF- I , in order to elucidate the modulation action of copper on liver and somatotropin axis correlation factor and internal mechanism of growth-promoting of copper. Quantitative changes of gene expression of IGF- I and IGFBP in blood were detected by growth promoting experiment,RIA and quantitative PCR. These results indicated that the addition of copper(125-250 mg/kg) in food improved the IGF- I gene expression, significantly increased the average body weight gain. These results indicated that copper stimulates growth by the synthesis and secretion of some factors of axis.

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