Clinical Efficacy of Compound Fluconazole Ointment

ZHANG Rui-li2,HAO Zhi-hui1,HOU Jia-fa3,LIU Yuan-yuan2,CUI Liang-liang2,QIU Mei2(1.College of Chemistry and Pharmaceutical Sciences,Qingdao Agricultural University,Qingdao,Shandong,266111,China;2.Continent Pharmaceutical CO.,LTD.,Qingdao,Shandong,266061,China;3.College of Veterinary Medicine,Nanjing Agricultural University,Nanjing,Jiangsu,210095,China)

compound fluconazole ointment;oridermyl;administration regimen;clinical trial

To study the efficacy of compound fluconazole ointment in the treatment of canine auditory canal fungous and bacterial infections.artificially and naturally infected dogs were used in tests,with oridermyl as a control for 42 d clinical efficacy studies.The clinical trial results in artificially infected dogs showed that: compound fluconazole and oridermyl had a better therapeutic effect for canine ear infection,there was no significant difference(P> 0.05);the cure rate of the recommended dose group and the double dose group of compound fluconazole ointment were higher than 90%,and compared with the control group,the difference was extremely significant(P<0.01).The clinical trial data in naturally infected dogs showed the cure rates of compound fluconazole for fungal and bacterial ear infection were higher than 90%,and the difference was not significant(P> 0.05).The recommended dose of compound fluconazole ointment(0.5 mL /ear,1 time/d,continuous administration for 4 weeks) had a better efficacy,and can be used for canine ear bacterial and fungal infections.