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胰高血糖素样肽-2与肠道营养调控

作  者:
刘旭;周定刚;唐勇
关键词:
GLP-2;GLP-2R;胃肠道激素;肠道营养
摘  要:
胰高血糖素样肽-2(glucagon-like peptide2,GLP-2)是含有33个氨基酸的多肽,是由肠道特异性组织和L细胞分泌的胰高血糖素原基因编码的产物。GLP-2可以刺激肠内细胞增殖,抑制凋亡和蛋白质水解,从而对小肠和大肠均有特异性的营养作用;同时,还能抑制胃的运动和胃酸的分泌,增强己糖转运酶的活力,抑制摄食。
译  名:
胰高血糖素样肽-2与肠道营养调控
关键词:
glucagon-like peptide 2;glucagon-like peptide 2 receptor;gut hormone;enteral nutrition
摘  要:
Glucagon-like peptide-2(GLP-2)is a gut hormone that is post-translationally processed from the proglucagon gene product localized in enteroendocrine L cells in response to enteral nutrition,especially carbohydrate and lipid.Many research enunciated GLP-2 can stimulate cell inside the bowell to proliferate,restrain apoptosis and protein hydrolyze,thus all having the nourishment function for the small intestine and the large intestine.And GLP-2 returning can repress gastric sport and secretion of stomach acid,strengthening hexosyltransferase activity,restrain food intake.

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