关键词：
花椒精;卵巢切除大鼠;血脂;胆汁酸;中性固醇
摘 要：
目的:探讨花椒精对卵巢切除大鼠脂质代谢的影响。方法:将40只雌性Sprague-Dawley(SD)大鼠随机分为5组,其中1组进行伪切除手术(Sham)作为对照组,另外4组进行双侧卵巢切除手术(ovariectomy,OVX),恢复饲喂一周后,分为空白组和灌胃花椒精高(15 mg/kg)、中(10 mg/kg)、低(5 mg/kg)剂量组。灌胃4周后解剖,检测大鼠血脂、肝脂及小肠和粪便中胆汁酸含量等指标。结果:灌胃花椒精可降低血清中甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)和非高密度脂蛋白胆固醇(non-high density lipoprotein cholesterol,non-HDL-C)的浓度(P<0.05),升高HDL-C的浓度;降低肝脏中脂肪、TC、TG的含量(P<0.05);增加大鼠排便量、促进小肠内容物和粪便中胆汁酸以及粪醇、胆固醇等中性固醇的排泄,且存在明显的剂量效应。结论:花椒精可改善卵巢切除SD大鼠因雌性激素缺乏而引起的高脂血症,可能与促进胆汁酸和中性固醇的排泄有关。
译 名：
Effect of Oleoresin from Zanthoxylum bungeanum on Lipid Metabolism in Ovariectomized Rats
作 者：
YOU Yuming;REN Wenjin;LIU Qingqing;LIU Xiong;College of Food Science,Southwest University;College of Forestry and Life Science,Chongqing University of Arts and Sciences;
关键词：
Zanthoxylum bungeanum oleoresin;;ovariectomized rats;;serum lipid;;bile acids;;neutral steroid
摘 要：
Objective:To investigate the effect of oleoresin from Zanthoxylum bungeanum on lipid me tabolism in ovariectomized rats.Methods:Forty female Sprague-Dawley rats were randomly divided into five groups;one group was sham-operated as sham control,and the other four groups were subjected to ovariectomy.After one week of feeding postsurgery,the rats from the sham control and ovariectomy groups were daily orally administered with 0,15(OVX-HD),10(OVX-MD),and 5 mg/kg(OVX-LD) Zanthoxylum bungeanum oleoresin.After fo ur weeks,all the rats were sacrifi ced for the analysis of triglyceride(TG),cholesterol(TC) in serum and liver,bile acids in small intestine and feces.Results:By the administration of Zanthoxylum bungeanum oleoresin,the concentrations of triglyceride,cholesterol,low-density lipoprotein cholesterol and non high-density lipoprotein cholesterol in serum were significantly decreased(P < 0.05) as well as the concentrations of fat,triglyceride and cholesterol in liver,but the excretion of fec es,bile acid contents in small intestine and feces,and the excretion of neutral steroids were increased.Conclusion:Zanthoxylum bungeanum oleoresin can ameliorate lipid metabolism in estrogen defi ciency-induced hypercholesterolemia rats by promoting the excretion of bile acids and neutral steroids.
