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Position: Home > Articles > Research Progress of Integrin β1 Structure and Biological Function Chinese Journal of Animal Science 2016,52 (3) 76-80

整联蛋白β1结构及生物学功能的研究进展

作  者:
潘丽;赵元;秦贵信
单  位:
动物生产及产品质量安全省部共建教育部重点实验室吉林省动物营养与饲料科学重点实验室吉林农业大学动物科学技术学院
关键词:
整联蛋白;β1亚基;结构;生物学功能;信号转导
摘  要:
整联蛋白是一类由α、β亚基结合成的异二聚体受体蛋白,主要介导细胞与细胞,细胞与细胞外基质之间的相互作用。整联蛋白β1亚基是整联蛋白家族成员中重要的一种,通过介导细胞双向信号转导,调节多种细胞生物学过程。随着对整联蛋白亚基生物学特性研究的不断深入,整联蛋白β1在动物生产及疾病治疗中的应用已被引起广泛的关注。本文旨在从分子生物学水平对整联蛋白β1亚基的结构,介导的信号转导通路以及生物学功能进行综述,为相关整联蛋白的研究内容和方法提供重要的信息。
译  名:
Research Progress of Integrin β1 Structure and Biological Function
作  者:
PAN Li;ZHAO Yuan;QIN Gui-xin;Key Laboratory of Animal Production,Product Quality and Security,Ministry of Education,Key Laboratory of Animal Nutrition and Feed Science,College of Animal Science and Technology,Jilin Agricultural University;
关键词:
integrin;;β1 subunit;;structure;;biological function;;signal transduction
摘  要:
Integrins are trans membrane heterodimeric glycoprotein receptors that consist of α and β subunit.They mainly mediated interaction between cell to cell and cells to extracellular matrix.Integrin β1 is an important subgroup of integrin family and regulates cell biological process by transmitting bidirectional signaling across the plasma membrane.With the deep research of integrin subunits biological characteristics,application of integrin β1 in animal production and disease treatment has gradually become a research hotspot.The purpose of this review mainly describes the structure,transduction signaling pathway and biological function of integrin β1,with a goal to provide important information for research contents and methods of related integrins.

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