Position: Home > Articles > Advance in Isoprenoids Biosynthesis Pathway and DOXP Reductoisomerase in Apicomplexa
Progress in Veterinary Medicine
2012,33
(2)
79-82
顶复门原虫类异戊二烯生物合成途径及其关键酶的研究进展
作 者：
廖申权;吴彩艳;戚南山;吕敏娜;覃宗华;孙铭飞
单 位：
广州英赛特生物技术有限公司;广东省农业科学院兽医研究所
关键词：
2C-甲基-D-赤藓糖醇-4-磷酸途径;1-脱氧-D-木酮糖-5-磷酸还原异构酶;药靶;顶复门原虫
摘 要：
顶复门原虫包括疟原虫(Plasmodium spp.)、刚地弓形虫(Toxoplasma gondii)、艾美耳球虫(Eimeria spp.)、锥虫(Trypanosoma spp.)、泰勒虫(Theileria spp.)及巴贝斯虫(Babesia spp.)等一大类引起严重人畜疾病的寄生性原虫。顶复门原虫利用2C-甲基-D-赤藓糖醇-4-磷酸(MEP)途径合成类异戊二烯前体物质,这些化合物对于维持顶复门原虫的生存具有十分重要的作用。1-脱氧-D-木酮糖-5-磷酸(DOXP)还原异构酶是MEP途径的关键酶,对其作用机理及抑制剂的筛选研究已取得重要进展。论文对顶复门原虫类异戊二烯的MEP途径,DOXP还原异构酶的作用机理及靶标研究进展进行综述。
译 名：
Advance in Isoprenoids Biosynthesis Pathway and DOXP Reductoisomerase in Apicomplexa
作 者：
LIAO Shen-quan1,WU Cai-yan1,QI Nan-shan1,Lü Min-na1,QIN Zong-hua2,SUN Ming-fei1 (1.Institute of Veterinary Medicine,Guangdong Academy of Agricultural Sciences,Guangdong Common Lab of Veterinary Public Health, Guangzhou,Guangdong,510640,China;2.Guangzhou Insighter Biotechnology Co.,Ltd,Guangzhou,Guangdong,510663,China)
关键词：
2C-methyl-D-erythritol-4-phosphate pathway;1-deoxy-D-xylulose-5-phosphate reductoisomerase;drug target;Apicomplexa
摘 要：
Parasites of the phylum Apicomplexa include many important human and veterinary pathogens such as Plasmodium spp.,Toxoplasma gondii,Eimeria spp.,Trypanosoma spp.,Theileria spp.,and Babesia spp.The biosynthesis of isoprenoids is achieved by the 2C-methyl-D-erythritol-4-phosphate(MEP) pathway,which is closely related to the survival of apicomplexan parasites.1-deoxy-D-xylulose 5-phosphate reductoisomerase(DXR) is a key enzyme of the pathway.The research on the catalytic mechanism and inhibitor selection of DXR made important progress.This review focused on recent developments on the MEP pathway and the characterization of DXR in Apicomplexa.
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