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Position: Home > Articles > Effects of extract of Ginkgo biloba(EGb) on immunocyte apoptosis relevant proteins Bcl-2 and Bax in spleen of rat Chinese Journal of Veterinary Science 2007,27 (2) 237-239

银杏叶提取物对大鼠脾脏免疫细胞凋亡相关蛋白Bcl-2和Bax表达的影响

作  者:
何玉龙;范光丽;吴月红;阿依木古丽;田光明;王根辈
单  位:
西北农林科技大学动物科技学院
关键词:
银杏叶提取物;Bcl-2;Bax;卵巢摘除;脾脏;免疫自稳状态
摘  要:
24只SD雌性大鼠随机分为假手术组(A组)、卵巢摘除组(B组)、卵巢摘除并银杏叶提取物(EGb)治疗组(C组),利用免疫组化染色检测脾脏中Bcl-2蛋白和Bax蛋白的表达。结果发现,B组大鼠脾脏内Bcl-2蛋白表达显著减少,而Bax蛋白表达显著增加;C组Bcl-2蛋白表达明显回升(P<0.01),而Bax蛋白表达明显回落(P<0.05)。表明银杏叶提取物可通过上调Bcl-2蛋白表达,下调Bax蛋白表达,改变Bcl-2与Bax的比值(Bcl-2/Bax)而维护脾脏的免疫自稳状态。
译  名:
Effects of extract of Ginkgo biloba(EGb) on immunocyte apoptosis relevant proteins Bcl-2 and Bax in spleen of rat
作  者:
HE Yu-long,FAN Guang-li*,WU Yue-hong,Ayimuguli,TIAN Guang-ming,WANG Gen-bei (College of Animal Science and Technology,Northwest University of Agriculture and Forestry,Yangling, Shaanxi 712100,China)
关键词:
EGb;Bcl-2;Bax;ovariectomy;spleen;immunologic homeostasis
摘  要:
Using SP immunohistochemistry staining to explore the effect of EGb on Bcl-2 and Bax positive expression in spleen of ovariectomized rats.24 SD rats were divided into 3 groups:the shamming operated group(A),ovariectomized group(B),and the ovariectomized and EGb treated group(C).As the result,the expression of Bcl-2 decreased,while the expression of Bax increased in ovariectomized group;on the contrary,the expression of Bcl-2 increased(P<0.01) and the expression of Bax decreased(P<0.05) in the ovariectomized and EGb treated group.These results indicated that EGb enable the spleen to maintain its immunologic homeostasis by upregulating the expression of Bcl-2 and downregulating the expression of Bax.

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