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当前位置: 首页 > 文章 > 膳食中晚期糖基化终产物对大鼠肾脏的影响 食品科学 2013,34 (21) 315-320
Position: Home > Articles > Effect of Dietary Advanced Glycation End Products on Diabetic Rat Kidney FOOD SCIENCE 2013,34 (21) 315-320

膳食中晚期糖基化终产物对大鼠肾脏的影响

作  者：
张双凤;苏亚儒;李巨秀
单  位：
西北农林科技大学食品科学与工程学院
关键词：
晚期糖基化终产物;糖尿病;肾病;氧化应激
摘  要：
以SD大鼠为实验动物,建立糖尿病大鼠模型,用含量不同的晚期糖基化终产物(AGEs)饲料饲喂糖尿病鼠和正常鼠8周,研究大鼠肾脏系数、血肌酐、血清荧光值、肾组织超氧化物歧化酶(SOD)、丙二醛(MDA)、还原型谷胱甘肽(GSH)的变化,观察AGEs摄入对大鼠肾脏的影响,并对其机制进行探讨,以评估膳食中AGEs的安全性。结果表明:AIN-93G饲料经过高温烘烤(125℃,3h),荧光性AGEs增加4倍左右。从第4周到第8周,AGEs实验组大鼠的肾脏损伤加剧,大鼠肾脏氧化应激加剧。喂养至第8周,与低AGEs饲料糖尿病鼠组相比,高AGEs饲料糖尿病鼠组的肾脏系数((14.84±2.09)g/kg)、血肌酐浓度((40.55±3.51)mol/L)、血清荧光值((898.60±58.07)AU)、MDA含量((5.05±0.42)nmol/mgpro)均显著升高(P<0.05)、SOD活力((89.11±11.07)U/mgpro)、GSH含量((4.12±0.58)mg/gpro)均降低,但差异不显著(P>0.05);与低AGEs饲料正常鼠组相比,高AGEs饲料正常鼠组的肾脏系数、血肌酐浓度、血清荧光值、MDA含量分别上升了11.86%、31.76%、44.49%、163.02%,SOD活力、GSH含量分别下降了50.56%、65.23%。因此,高AGEs饲料促进糖尿病鼠和正常鼠的肾功能恶化,作用机制可能与氧化应激有关。限制AGEs的摄入,可以作为延缓糖尿病肾病恶化的措施之一。
译  名：
Effect of Dietary Advanced Glycation End Products on Diabetic Rat Kidney
作  者：
ZHANG Shuang-feng;SU Ya-ru;LI Ju-xiu;College of Food Science and Engineering,Northwest A&F University;
关键词：
advanced glycation end products;;diabetes;;nephropathy;;oxidative stress
摘  要：
Forty-eight SD rats were used as experimental animals to establish diabetic rat models by intraperitoneal injection of streptozotocin.Changes in kidney coefficient,serum creatinine,serum fluorescence,superoxide dismutase(SOD) in kidney tissue,malondialdehyde(MDA),and reduced glutathione(GSH) were evaluated on rats after feeding with advanced glycation products at various concentrations for 8 weeks.In addition,the effect and mechanism of dietary AGEs on rat kidney were investigated to evaluate the safety of AGEs in diet.The results showed that fluorescent AGEs of AIN93G diet revealed 4 fold increase after baking at high temperature(125 ℃,3 h).Kidney injury caused by AGEs was enhanced during weeks 4 to 8.Approximately 8 weeks later,compared with low AGEs diet,kidney coefficient((14.84±2.09) g/kg),serum creatinine concentration((40.55±3.51) μ mol/L),serum fluorescence value((898.6±58.07) AU) and MDA content((5.05±0.42) nmol/mg pro) in diabetic rats fed on high AGE diet were significantly higher(P<0.05),while SOD activity((89.11±11.07) U/mg pro) and GSH level((4.12±0.58) mg/g pro) were decreased without significant difference(P>0.05); compared with low AGEs,kidney coefficient,serum creatinine concentration,serum fluorescence value and MDA content of normal rats fed on high AGEs diet were increased by 11.86%,31.76%,44.49% and 163.02%,respectively,while SOD activity and GSH content were decrease by 50.56% and 65.23%,respectively.In conclusion,high AGEs diet can promote the deterioration of renal function in rats and its mechanism may be associated with oxidative stress.Limited intake of AGEs can be introduced as one of the strategies to slow down the deterioration of diabetic nephropathy.

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