当前位置: 首页 > 文章 > 牛初乳粉对调节免疫低下大鼠免疫功能的研究 新疆农业科学 2004,41 (6) 422-426
Position: Home > Articles > Effects of Bovine Colostrum Powder on Modulating Immune Function of Rats with Poor Immunity Xinjiang Agricultural Sciences 2004,41 (6) 422-426

牛初乳粉对调节免疫低下大鼠免疫功能的研究

作  者:
肖辉;张月明;于亚鹭;田雨露;刘岳强
单  位:
新疆医科大学公共卫生学院营养与食品卫生学教研室
关键词:
牛初乳粉;免疫低下大鼠;免疫调节;氢化可的松
摘  要:
研究牛初乳粉对免疫低下大鼠免疫功能调节作用,初步探讨其机制。将SD大鼠随机分为3组,空白对照组、模型组、牛初乳粉组,每组大鼠10只,其中模型组、牛初乳粉组肌注免疫抑制剂氢化可的松建立SD大鼠免疫低下模型,牛初乳粉组用牛初乳粉干预14d后,测定几项免疫指标。实验表明,牛初乳粉可以明显提高免疫低下大鼠血中白细胞数;牛初乳粉对免疫低下大鼠脾脏具有保护作用;牛初乳粉可以明显提高淋巴细胞增殖能力,增强免疫低下大鼠抗体分泌细胞分泌功能,提高血清溶血红素的含量;牛初乳粉可以明显提高免疫低下大鼠血清白介素-1的含量,有增加血清白介素-2、肿瘤坏死因子含量的趋势。实验还表明,牛初乳粉具有免疫调节作用,其机制与牛初乳粉明显提高大鼠血清白介素-1、血清白介素-2、肿瘤坏死因子含量有关。
译  名:
Effects of Bovine Colostrum Powder on Modulating Immune Function of Rats with Poor Immunity
作  者:
XIAO Hui,ZHANG Yue-ming,YU Ya-lu,TIAN Yu-lu,LIU Yue-qiang(Department of Nutrition and Food Hygiene of School of Public Health,Xinjiang Medical University,Urumqi 830054,China)
关键词:
bovine colostrum powder;immune function;hydrocortisone;rat
摘  要:
The effects of bovine colostrum powder on modulating immune function of rats with poor immunity were studied.Methods were applied in the experiment :immunodeficient model rats induced by hydrocortisone were filled stomaches with bovine colostrum powder one time a day .After 14 days and the immune modulation indicators in rats were detected .Results were shown:the experiment indicated that bovine colostrum powder remarkably enchanced total number of peripheral blood cell ,T lymphocytes proliferation and transformation were induced by ConA , production of IL-1 and the serum hemolysin level in rats.The function of antibody formation cells were also significantlg enhanced.Conclusion was drawn: bovine colostrum powder had the function of enhancing the immune responses in rats induced with immunnodeficient hydrocortisone.Its mechanism may be associated with the enhancement of interleukin -2 activity.

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