关键词：
刺五加苷;亚急性衰老模型;丙二醛;超氧化物歧化酶;白介素-2;白介素-6
摘 要：
目的:研究刺五加苷(CG)对半乳糖亚急性衰老模型大鼠的影响。方法:用D-半乳糖(D-gal)造成大鼠亚急性衰老模型,CG按3.6、7.2、14.4g/kgbw·d连续灌胃,检测大鼠的脏器指数,测定T淋巴细胞增殖功能,组织中超氧化物歧化酶(SOD)活力、丙二醛(MDA)浓度,血清IL-2(IL-2)、白介素-6(IL-6)浓度。结果:CG能明显提高衰老模型大鼠胸腺指数和T淋巴细胞增殖功能,增强组织SOD活性,降低组织MDA浓度,提高血清IL-2浓度,降低血清IL-6浓度。结论:CG可以清除亚急性衰老模型大鼠的自由基和改善免疫系统。
译 名：
Effect of Ciwujia Glycosides on D-Galactose-induced Subacute Intoxicating Rats
作 者：
MENG Xian-jun1,YANG Ping1,2,ZHANG Chun-hong1 (1. College of Food Science,Shenyang Agricultural University,Shenyang 110161,China ; 2. Liaoning Institute for Medical Research Foundation,Shenyang 110101,China)
关键词：
Ciwujia glycosides;subacute intoxicating rats;malondialdehyde (MDA);superoxidedismutase (SOD); IL-2;IL-6
摘 要：
Objective:To explore the effect of Ciwujia glycosides on D-galactose-induced subacute intoxicating rats. Methods:Subacute intoxication models of rats were constructed by administering them with 100 mg/(kg bw·d) of D-galactose through intraperitoneal injection. Healthy SD rates were randomly divided into 5 groups of 8 rate each (half female and half male):control group,subacute intoxication model group,and low-,medium-and high-dose-treated groups administered with 3.6,7.2,and 14.4 g/(kg bw·d) of Ciwujia glycosides by gavage,respectively. After continued administration for 8 weeks,all the rats were sacrificed,and then the thymus index and spleen index were measured and the proliferation capability of T lymphocyte,tissue SOD activity and MDA concentration,and serum interleukin-2 (IL-2) and interleukin-6 (IL-6) concentrations were assayed. Results:Pronounced rises in thymus index,proliferation capability of T lymphocyte,tissue SOD activity and serum IL-2 concentration and falls in tissue MDA concentration and serum IL-6 concentration were observed in Ciwujia glycosides-treated rats in comparison with subacute intoxicating ones. Conclusion:Ciwujia glycosides can effectively scavenge free radicals and improve the immune system in D-galactose induced subacute intoxicating rats.
