Position: Home > Articles > The Expression of VEGF and TGF-β_1 in Synovial Membrane of the Patients of Knee Joint Pannus
Journal of Shihezi University(Natural Science)
2010,28
(1)
78-81
膝关节镜下所见血管翳患者滑膜中VEGF、TGF-β_1的表达及其意义
作 者：
陈磊;王维山;王永明;史晨辉
单 位：
石河子大学医学院第一附属医院
关键词：
血管翳;滑膜;VEGF;TGF-β1
摘 要：
为探讨VEGF、TGF-β1两因子与血管翳的相互关系,为血管翳的临床治疗提供指导,选择行膝关节镜手术且发现在1~3个部位出现血管翳的患者,根据血管翳出现部位的数量将其滑膜标本筛选分为3个实验组,每组15例,其中未发现血管翳患者滑膜的标本为对照组。采用免疫组化技术检测与观察VEGF、TGF-β1在各组中的表达,分析其表达意义。结果表明:与对照组相比,实验组中的VEGF、TGF-β1呈高表达,差异有统计学意义(P<0.05),且与血管翳出现的部位数相关,随着出现部位的增加,VEGF、TGF-β1的阳性表达率也随之增高;将VEGF与TGF-β1的检验结果进行Spearman相关分析,结果显示两因子的阳性率呈正相关(r=0.910,P=0.000)。这表明,VEGF、TGF-β1的过度表达与膝关节血管翳的形成密切相关,检测膝关节滑膜组织中VEGF和TGF-β1的表达有助于预测血管翳的发展趋势。
译 名：
The Expression of VEGF and TGF-β_1 in Synovial Membrane of the Patients of Knee Joint Pannus
作 者：
CHEN Lei,WANG Weishan,WANG Yongming,SHI Chenhui (The First Affiliated Hospital,Shihezi University School of Medicine,Shihezi 832002,China)
关键词：
pannus;synovial membrane;VEGF;TGF-β1
摘 要：
To elucidate VEGF and TGF-β1 expression in synovial membrane of the patients of knee joint pannus by analyzing of them.15 synovial membrane specimens of the patients of knee joint pannus in every groups that the pannus was found in 1~3 parts by arthroscope were selected as test group.15 specimens that the pannus was not found by arthroscope were selected as control group.Distribution of VEGF and TGF-β1 in every group was observed by immunohistochemistry.The expression of them was statistically compared.The expression of VEGF and TGF-β1 in control group was significantly lower than the test group(P<0.05).TGF-β1 was significantly correlated with expression of VEGF(P<0.05).VEGF and TGF-β1 were involved and played a important part in formation and progression of pannus.Detecting the expression of VEGF and TGF-β1 in synovial membrane of knee joint can conduce to estimate the progression of pannus.
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