单 位：
江南大学食品科学与技术国家重点实验室;河南工业大学小麦和玉米深加工国家工程研究中心
关键词：
蛋氨酸限制;延长寿命;代谢综合征;肿瘤;健康益处;实现策略
摘 要：
蛋氨酸是人体必需氨基酸中唯一的一种含硫氨基酸，参与机体蛋白质合成、转硫途径和一碳代谢等重要代谢通路。近年来国内外大量研究表明限制饮食中蛋氨酸摄入能产生许多有益于机体健康的生理功能。本文全面地综述蛋氨酸限制（methionine restriction,MR）饮食改善肠道健康、延长寿命、减肥降脂、改善胰岛素敏感性和糖尿病、缓解动脉粥样硬化和心血管疾病、改善学习记忆功能、抗肿瘤和癌症等健康益处及其对骨骼、骨骼肌和蛋白质合成的影响；总结目前国内外已报道的采用蛋白质限制饮食、纯素食饮食、基于单体氨基酸配制的饮食、口服蛋氨酸酶及注射重组蛋氨酸酶5种方法实现MR的优点和缺点；并且对未来的重点研究方向进行展望。通过了解MR的健康益处及其实现策略，可为低蛋氨酸系列新食品的开发应用以及MR健康功能的实现提供理论参考。
作 者：
LU Manman;QIAN Jing;YANG Yuhui;XIE Yanli;LE Guowei;National Engineering Research Center of Wheat and Corn Further Processing, Henan University of Technology;State Key Laboratory of Food Science and Technology, Jiangnan University;
关键词：
methionine?restriction;;prolonging?lifespan;;metabolic?syndrome;;tumor;;health?benefits;;implementation?strategies
摘 要：
Methionine is the only essential sulfur-containing amino acid required for the human body and is involved in important metabolic pathways including protein synthesis, transsulfuration, and one-carbon metabolism. However, in recent years, a large number of studies have shown that restricting dietary methionine intake exerts many physiological functions beneficial to body health. This article comprehensively summarizes the benefits of methionine restriction(MR) including promoting gut health, prolonging lifespan, reducing lipid accumulation and body mass, increasing insulin sensitivity,ameliorating diabetes, atherosclerosis and other cardiovascular diseases, improving learning and memory function, and anti-tumor and anti-cancer effects, as well as the effects of MR on bone and skeletal muscle function and protein synthesis.In addition, the strengths and weaknesses of five MR strategies including protein-restriction diet, vegan diet, diet formulation based on monomeric amino acid, oral methioninase, and injection of recombinant methioninase are reviewed in this article.It also discusses future major research directions, which may provide a theoretical reference for the development and application of new foods containing low levels of methionine and the realization of the health functions of MR.
