当前位置: 首页 > 文章 > 伊曲康唑注射液对小鼠的亚慢性毒性研究 中国兽医杂志 2013,49 (10) 75-78
Position: Home > Articles > Studies on Sub-Chronic Toxicity Test of Itraconazole Injection in Mice Chinese Journal of Veterinary Medicine 2013,49 (10) 75-78

伊曲康唑注射液对小鼠的亚慢性毒性研究

作  者:
刘云;李德军;姜岩;王海彬;祝玉卿;陈曦;陈亮
单  位:
东北农业大学动物医学学院
关键词:
伊曲康唑;注射液;小鼠;毒性
摘  要:
80只小鼠随机分为4组,采用背部皮下给药法,给药剂量分别为30mg/kg·d,60mg/kg·d和90mg/kg·d,按0.01mL/g体重连续给药一个月,对照组给予生理盐水。记录体重变化,检测血液生化指标,制作肝肾组织切片。结果表明,在高剂量组中,小鼠在第28天称重时,平均体重最轻,与其他3组比较,差异显著(P<0.05),GPT出现升高,部分小鼠的肝脏出现变性,甚至坏死,其他各组未见异常变化。
译  名:
Studies on Sub-Chronic Toxicity Test of Itraconazole Injection in Mice
作  者:
LIU Yun;LI De-jun;JIANG Yan;WANG Hai-bin;ZHU Yu-qing;CHEN Xi;CHEN Liang;College of Veterinary Medicine,Northeast Agriculture University;
关键词:
itraconazole;;injection;;mice;;toxicity
摘  要:
Eighty Mice were randomly divided into 4groups,the mice were injected subcutaneously with 30mg·kg-1·d-1,60mg·kg-1·d-1 and 90mg·kg-1·d-1 in the napes and backs,continuously for one month at the dose of 0.01mL·g-1,control group received normal saline.Weights were recorded,blood biochemical indicators were examined and the tissue section of liver and kidney were prepared.The result indicated that the average weight was the lightest at 28d,compared to the other three groups,the difference was significant(P<0.05)and the GPT appeared higher,some mice′s livers had degeneration,even necrosis in the high dose group.Other groups had no abnormal change.

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