Position: Home > Articles > Analysis of 2,3-Difulor-5-Chloropyridine and 3,5-Dichloro-2-Fluoropyridine by HPLC
Modern Agrochemicals
2022,21
(1)
39-41
2,3-二氟-5-氯吡啶和3,5-二氯-5-氟吡啶高效液相色谱分析
作 者：
王利;陆雪芳;杜辉
单 位：
南通江山农药化工股份有限公司
关键词：
2,3-二氟-5-氯吡啶;3,5-二氯-5-氟吡啶;高效液相色谱;分析
摘 要：
建立一种同时测定2,3-二氟-5-氯吡啶和3,5-二氯-5-氟吡啶的高效液相色谱分析方法。使用乙腈和酸性水作为流动相,以ZORBAX XDB-C_(18)柱为分离柱,紫外检测器在254 nm波长下对2,3二氟-5氯吡啶和3,5二氯-5-氟吡啶进行高效液相色谱分离和定量分析。采用该分析方法,2,3-二氟-5氯吡啶和3,5-二氯-5-氟吡啶样品分离效果较好,两者线性相关系数分别为0.999 6和0.999 5;标准偏差分别为0.18%和0.14%;变异系数分别为0.34%和0.36%;平均回收率分别为99.78%和99.80%。该分析方法实现了2,3-二氟-5-氯吡啶和3,5-二氯-5-氟吡啶的分离,操作快捷简便,精密度和准确度高,满足两者的定量检测的分析要求。
译 名：
Analysis of 2,3-Difulor-5-Chloropyridine and 3,5-Dichloro-2-Fluoropyridine by HPLC
作 者：
WANG Li;LU Xuefang;DU Hui;Nantong Jiangshan Agrochemical & Chemicals Co., Ltd.;
关键词：
2,3-difulor-5-chloropyridine;;3,5-dichloro-2-fluoropyridine;;HPLC;;analysis
摘 要：
This study aimed to establish a method to detect 2,3-difulor-5-chloropyridine and 3,5-dichloro-2-fluoropyridine with one column under the same HPLC condition. The determination of 2,3-difulor-5-chloropyridine and 3,5-dichloro-2-fluoropyridine were conducted by HPLC with ZORBAX XDB-C18 column, UV wavelength detector, and the mobile phase of acetonitrile and acid water at a wavelength of 254 nm. The proposed method was effective and efficient for the separation and measurement of 2,3-difulor-5-chloropyridine and 3,5-dichloro-2-fluoropyridine. The linear correlation coefficients for the two target components were 0.999 6 and 0.999 5, and the average recoveries were 99.78% and 99.80%,with the standard deviation of 0.18% and 0.14%, and the variation coefficient of 0.34% and 0.36%. This method showed a potential for determining 2,3-difulor-5-chloropyridine and 3,5-dichloro-2-fluoropyridine due to its simple, convenient processing, high separation and accuracy.
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