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Position: Home > Articles > Study on Activity of Mycelium Proteins from Pholiota squarrosa Acta Agriculturae Jiangxi 2008,20 (8) 103-105+107

食药用真菌翅鳞伞菌丝体蛋白活性的研究

作  者:
汪建敏;焦阳;吕凤霞;别小妹;王煜;陆兆新
单  位:
南京农业大学食品科技学院
关键词:
翅鳞伞;抗肿瘤蛋白;抗真菌;核酸内切酶
摘  要:
对翅鳞伞菌丝体的胞内粗蛋白进行分离、纯化、筛选,获得了抗水稻纹枯病菌的翅鳞伞纯化菌丝体蛋白PSPB-2。通过荧光显微镜观察PSPB-2对人肺癌细胞株(A549)的影响,发现PSPB-2会引起A549出现典型的细胞凋亡现象。进一步研究发现PSPB-2有限制性核酸内切酶的活性。说明菌丝体蛋白PSPB-2具有抗真菌作用的同时又具有抗肿瘤作用。
译  名:
Study on Activity of Mycelium Proteins from Pholiota squarrosa
作  者:
WANG Jian-min,JIAO Yang,LU Feng-xia,BIE Xiao-mei,WANG Yu,LU Zhao-xin(College of Food Scientific Technology,Nanjing Agricultural University,Nanjing 210095,China)
关键词:
Pholiota squarrosa;Antitumor protein;Antifungal;Endonuclease
摘  要:
Mycelium protein PSPB-2 was separated,purified and screened from the mycelium proteins of Pholiota squarrosa.PSPB-2 remarkably inhibited the human lung cancer cell line A549 through observation by fluorescence microscope.PSPB-2 had antifungal activity to A549.And the further research showed that PSPB-2 had inhibition to endonuclease.So mycelium protein PSPB-2 had the antitumor activity as well as antifungal activity.

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