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Position: Home > Articles > A Case of Histopathological Observation of Inborn Cryptorchid in Beagle Dog Progress in Veterinary Medicine 2016,37 (11) 133-135

一例比格犬先天性隐睾的组织病理学观察

作  者:
胡建廷;邱波;王韶艳;屈卉锦;王凤乾;张鑫;英永
单  位:
山东省药学科学院山东省化学药物重点实验室
关键词:
比格犬;隐睾;组织病理学
摘  要:
通过研究隐睾症比格(Beagle)犬睾丸、附睾的组织病理学改变,建立适用于GLP的实验动物背景性资料。采用常规组织学方法,对比格犬隐睾及正常侧睾丸、附睾进行光学显微镜观察,确定组织病理学变化特点。与正常组织相比,隐睾胶原纤维组织增生,睾丸曲细精管内仅见少量精原细胞及支持细胞。附睾间质增宽,间质内填充增生的胶原纤维,附睾管内精子缺如。需加强比格犬自发病变的病理监测,为药物安全性评价提供实验动物的背景资料。
译  名:
A Case of Histopathological Observation of Inborn Cryptorchid in Beagle Dog
作  者:
HU Jian-ting;QIU Bo;WANG Shao-yan;QU Hui-jin;WANG Feng-qian;ZhANG Xin;YING Yong;Shandong Pharmaceutical Academy,Shandong Provincial Key Laboratory of Chemical Drugs;
关键词:
Beagle dog;;cryptorchid;;histopathology
摘  要:
To study the histopathological changes of testis and epididymis in cryptorchid of a Beagle dog and establish the backgroud information of experimental animals for GLP.With conventional histological methods,the histopathological feature of cryptorchid was described with optical microscope.Compared with normal,cryptorchid collagen fiber tissue hyperplasia was found.Only a small amount of spermatogonia and Sertoli cells were observed in seminiferous tubules.Interstitial tissue broaden and filled with collagen fibers in epididymis.Sperms were not observed in ductus epididymidis.It is suggested that spontaneous lesions should be monitored so as to provide the shistopathological backgroud information of experimental animal for drug safety evaluation.

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