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Position: Home > Articles > Process for the Synthesis of Etoxazole Agrochemicals 2014,53 (10) 19-21

乙螨唑的合成工艺

作  者:
丁成荣;郭欣;张国富;沈俊杰
单  位:
浙江工业大学化学工程学院
关键词:
乙螨唑;一锅法;环合;合成
摘  要:
[目的]对乙螨唑的合成工艺进行研究,简化合成方法,提高乙螨唑收率,以满足工业化生产需求。[方法]以2,6-二氟苯甲酰胺为起始原料,经取代反应得到N-(1-甲氧基-2-氯-乙基)-2,6-二氟苯甲酰胺,然后与间叔丁基苯乙醚反应生成相应中间体,最后在氢氧化钠作用下环合得到乙螨唑。目标化合物及中间体结构经1H NMR确证。[结果]反应总收率73.4%,产品含量97.8%。[结论]该工艺收率高,操作简单,经济环保,条件温和,适合工业化生产。
译  名:
Process for the Synthesis of Etoxazole
作  者:
DING Cheng-rong;GUO Xin;ZHANG Guo-fu;SHEN Jun-jie;College of Chemical Engineering,Zhejiang University of Technology;
关键词:
etoxazole;;one-pot reaction;;cyclization;;synthesis
摘  要:
[Aims] The purpose of this article is to explore and optimize the synthetic method of the etoxazole,so as to meet the requirement of industrial production. [Methods] The N-(2-chloro-1-methoxyethyl)-2,6-difluorobenzamide can be obtained through substitution reaction using 2,6-difluorobenzamide as starting material,followed by reacting with 1-(tert-butyl)-3-ethoxybenzene to get the corresponding intermediates,finally the etoxazole was obtained through further cyclization. The structures of the product and the intermediates were confirmed by 1H NMR. [Results] The total yield was 73.4% and purity was as high as 97.8%. [Conclusions] The synthetic process has advantages of high yield,simple operation,economical and green process,which is suitable for industrial production.

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