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Position: Home > Articles > Effect of Abelmoschus manihot Flavonoids on Blood Lipid Levels of Hyperlipidemic Rats FOOD SCIENCE 2012,33 (1) 248-251

金花葵黄酮对高脂血症大鼠血脂的影响

作  者:
李芸;杨秀松;何计国
单  位:
国家食品药品监督管理局;中国农业大学食品科学与营养工程学院
关键词:
金花葵;黄酮;高脂血症
摘  要:
目的:探讨金花葵黄酮对高脂血症模型大鼠血脂的影响。方法:100只SD大鼠,按体质量随机分为6组;除空白对照组外,其余各组饲喂高脂饲料制作动物高脂血症模型;其中金花葵黄酮分为3、30、90mg/(kg.d)剂量组;阳性对照组灌胃洛伐他汀片10mg/(kg.d);空白对照组、阴性对照组灌胃10mL/(kg.d)蒸馏水,连续6周。每两周测定血脂相关指标,最后一周测定氧化型低密度脂蛋白(ox-LDL)。结果:3个剂量组大鼠血清血脂水平(总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C))及ox-LDL明显降低。结论:金花葵黄酮能缓解大鼠高脂血症,降低ox-LDL水平,延缓泡沫细胞的形成和动脉粥样硬化的发生。
译  名:
Effect of Abelmoschus manihot Flavonoids on Blood Lipid Levels of Hyperlipidemic Rats
作  者:
LI Yun1,YANG Xiu-song2,HE Ji-guo1,(1.College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China; 2.Training Center of State Food and Drug Administration,Beijing 100073,China)
关键词:
Abelmoschus manihot;flavonoids;hyperlipidemia
摘  要:
Objective: To explore the effect of Abelmoschus manihot flavonoids on blood lipids of hyperlipidemic rats.Methods: Totally 100 SD rats were divided randomly into 6 groups: normal control group,high-fat control group,lovastatin positive control group at the dose of 10 mg/(kg·d),and flavonoid groups at low,middle and high doses(3,30 mg/(kg·d) and 90 mg/(kg·d)).Except normal the control group,all groups were fed high-fat diet to establish a hyperlipidemia model.Normal control group and high-fat control group were given distilled water at the dose of 10 ml/(kg·d) once a day for 6 consecutive weeks.Serum TC,TG,HDL-C,LDL-C,and ox-LDL were determined after the last administration.Results: Compared with the control group,serum TC,TG,LDL-C and ox-LDL revealed a significantly reduction in all the model groups.However,no significant difference in HDL-C level was observed among these groups.Conclusion: The flavonoids can delay the formation and development of arteriosclerosis.

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