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当前位置: 首页 > 文章 > 杏鲍菇甲壳素对大鼠实验性脂肪肝的预防作用 食品科学 2016,37 (5) 219-222
Position: Home > Articles > Preventive Effect of Chitin from Pleurotus eryngii on Fatty Liver in Rats FOOD SCIENCE 2016,37 (5) 219-222

杏鲍菇甲壳素对大鼠实验性脂肪肝的预防作用

作  者：
黄家福;林娇芬;欧一新;刘静娜;曹娜;庄诗怡;潘秋瑜;潘裕添
单  位：
闽南师范大学菌物产业工程技术中心
关键词：
杏鲍菇;甲壳素;实验性脂肪肝;预防
摘  要：
为研究杏鲍菇甲壳素对脂肪肝的预防作用,采用给脂肪肝模型大鼠对其喂食不同浓度杏鲍菇甲壳素,以考来烯胺为阳性对照,饲养5周后观察其血清中丙氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)、总胆固醇(total cholesterol,TC)、总甘油三酯(total triglycerides,TG)水平,肝脏组织中的TC、TG、丙二醛(malonaldehyde,MDA)水平、超氧化物歧化酶(superoxide dismutase,SOD)活性及肝组织病理学变化情况。结果表明:杏鲍菇甲壳素能极显著性(P<0.01)地降低大鼠血清中ALT、AST、TC、TG水平,显著提高肝脏组织中SOD活性(P<0.05)、降低MDA活性,减轻肝组织脂肪性样变,减少TC、TG在肝组织中积累,并呈现剂量效应,并值得注意的是,与考来烯胺组相比,杏鲍菇甲壳素高剂量组的预防效果与之相近,无差异性(P>0.05)。结论:杏鲍菇甲壳素具有预防脂肪肝形成的作用。
译  名：
Preventive Effect of Chitin from Pleurotus eryngii on Fatty Liver in Rats
作  者：
HUANG Jiafu;LIN Jiaofen;OU Yixin;LIU Jingna;CAO Na;ZHUANG Shiyi;PAN Qiuyu;PAN Yutian;Engineering Technological Center of Mushroom Industry, Minnan Normal University;
关键词：
Pleurotus eryngii;;chitin;;experimental fatty liver;;prevention
摘  要：
An experimental rat model of fatty liver was constructed to explore the preventive effect of chitin fromPleurotus eryngii on fatty liver. The rats were fed chitin at various concentration levels while cholestyramine was used as a positive control. After 5 weeks, the levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), total cholesterol(TC) and total triglycerides(TG) in serum and the levels of malonaldehyde(MDA) and superoxide dismutase(SOD) in liver were detected and pathological changes in liver were examined. Results showed the levels of ALT, AST, TC and TG in serum and the levels of TC, TG and MDA in liver significantly decreased(P < 0.01), and SOD activity significantly increased(P < 0.05) after administration with P. eryngii chitin for 5 weeks. Moreover, fatty degeneration in liver tissue was alleviated, and the levels of TC and TG were reduced in liver tissue. Furthermore, the hepatoprotective activity of P. eryngii chitin(PC) was dose dependent. Notably, the preventive effect of high-dose PC was similar to that of cholestyramine(P < 0.05). All these results indicated that P. eryngii chitin has the potential to prevent fatty liver disease in rats.

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