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农业科学学报 (英文)
2023,22
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Position: Home > Articles > Characterization of a blaCTX-M-3, blaKPC-2 and blaTEM-1B co-producing IncN plasmid in Escherichia coli of chicken origin
Journal of Integrative Agriculture
2023,22
(1)
Characterization of a blaCTX-M-3, blaKPC-2 and blaTEM-1B co-producing IncN plasmid in Escherichia coli of chicken origin
作 者：
Wang Wen-jing;Wang Yi-fu;Jin Ya-jie;Song Wu-qiang;Lin Jia-meng;Zhang Yan;Tong Xin-ru;Tu Jian;Li Rui-chao;Li Tao
单 位：
Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China;Guilin Med Univ, Guilin 541199, Peoples R China;Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China;Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
关键词：
bla(CTX-M-3);bla(KPC-2);bla(TEM-1B);IncN;plasmid;Escherichia coli
摘 要：
An extensively drug-resistant (XDR) Escherichia coli strain 258E was isolated from an anal swab sample of a chicken farm of Anhui Province in China. Genomic analyses indicated that the strain 258E harbors an incompatibility group N (IncN) plasmid pEC258-3, which co-produces bla(CTX-M-3), bla(KPC-2), bla(TEM-1B), qnrS1, aac(6 ')-Ib-cr, dfrA14, arr-3, and aac(6 ')-Ib3. Multiple genome arrangement analyses indicated that pEC258-3 is highly homologous with pCRKP-1-KPC discovered in Klebsiella pneumoniae from a patient. Furthermore, conjugation experiments proved that plasmid pEC258-3 can be transferred horizontally and may pose a significant potential threat in animals, community and hospital settings.
