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Position: Home > Articles > Advances in Genomics Research of Insect Baculovirus Journal of Henan Agricultural Sciences 2018 (9) 1-7

昆虫杆状病毒基因组学研究进展

作  者:
梁振普;刘雅静;张小霞;李鹏娟;王亮;张俊庆
关键词:
昆虫杆状病毒;基因组学;功能基因;应用
摘  要:
杆状病毒(Baculoviruses)是一类在自然界中专一性感染节肢动物的共价闭合双链环状DNA病原微生物。由于杆状病毒的宿主特异性高,其作为无公害生物杀虫剂在生物防治方面发挥重大作用。此外,杆状病毒已被开发成为高效的真核表达载体,广泛应用于药物研发、疫苗生产等领域,并作为基因治疗载体用于疾病的基因治疗。综述了获得全基因组序列的昆虫杆状病毒类别及其序列特征,以及昆虫杆状病毒基因组中的主要功能基因,包括RNA转录相关基因、DNA复制相关基因、结构蛋白基因等,也对其应用做了较为详尽的阐述。
译  名:
Advances in Genomics Research of Insect Baculovirus
作  者:
LIANG Zhenpu;LIU Yajing;ZHANG Xiaoxia;LI Pengjuan;WANG Liang;ZHANG Junqing;College of Life Sciences,Henan Agricultural University;
单  位:
LIANG Zhenpu%LIU Yajing%ZHANG Xiaoxia%LI Pengjuan%WANG Liang%ZHANG Junqing%College of Life Sciences,Henan Agricultural University
关键词:
Baculovirus;;Genomics;;Functional genes;;Application
摘  要:
Baculovirus is a kind of covalently closed double stranded circular DNA insect virus. Because of the host specificity of baculovirus,it plays a major role in biological control as a pollution-free biological insecticide. In addition,baculovirus has been developed as an efficient eukaryotic expression vector and is widely used in drug development,vaccine production and so on,meanwhile used in gene therapy of disease as a gene therapy vector. This paper reviews recent research progress on the genomics of insect baculovirus,including its sequence characteristics and main functional genes such as transcription related genes,DNA replication related genes,and structure related genes,and also gives a detailed description of its application.

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