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当前位置: 首页 > 文章 > 苷肽注射液诱导犬产生干扰素-γ试验的研究 中国兽药杂志 2013,47 (1) 20-22
Position: Home > Articles > Research on Generating IFN-γ of Canine Induced by the Glucoside Peptide Injection Chinese Journal of Veterinary Drug 2013,47 (1) 20-22

苷肽注射液诱导犬产生干扰素-γ试验的研究

作  者：
曲桂娟;孟轲音;王延卓;董晓庆;裴志花
单  位：
军事兽医研究所;吉林农业大学动物科技学院;乌兰察布职业学院生物技术系
关键词：
苷肽注射液;犬;干扰素-γ;免疫功能
摘  要：
为了探讨新型免疫增强剂———苷肽注射液对犬免疫功能的影响,以20只健康犬为研究对象,随机分为四组,每组5只,分别注射苷肽注射液、苷肽注射液和犬五联疫苗(狂犬病、犬瘟热、副流感、传染性肝炎与细小病毒性肠炎)、犬五联疫苗、生理盐水,各组犬于注射后0、2、7、15、21 d采血,检测不同组间IFN-γ含量的变化。结果表明:苷肽注射液单独应用及其与疫苗联合应用,在注射后2 d就可以显著提高IFN-γ水平,并且可以维持15 d;注射苷肽注射液联合犬五联疫苗组和单独注射苷肽注射液组IFN-γ含量显著高于单独注射犬五联疫苗组(P<0.05),说明苷肽注射液可以诱导γ-干扰素的产生,从而发挥其免疫增强的作用。
译  名：
Research on Generating IFN-γ of Canine Induced by the Glucoside Peptide Injection
作  者：
QU Gui-juan1,MENG Ke-yin2,WANG Yan-zhuo3,DONG Xiao-qing1,PEI Zhi-hua1(1.College of Animal Science and Technology,Jilin Agricultural University,Changchun,130118,China;2.Academy of Military Medicine, Changchun 130122,China;3.College of Biological Technology,Ulanqab,Inner Mongolia 012000,China)
关键词：
glucoside peptide injection;canine;IFN-γ;immune function
摘  要：
In order to explore the influence of glucoside peptide injection,a new immune strengthening agent on immune function of canine,twenty canines were randomly divided into four groups in this experiment.There were five canines in each group.The canines in four groups were respectively injected with glucoside peptide injection,glucoside peptide injection combined with canine 5-mixed vaccines(rabies,canine distemper,parainfluenza,the infectious hepatitis and canine parvovirus viral enteritis),canine 5-mixed vaccines and normal saline.In order to detect the change of the IFN-γ content between the different groups,the blood was collected before injection and on the second day,the seventh day,the fifteen day and the twenty-one day after injection.The results showed that IFN-γ secretion level was significantly raised on the second day and maintained for 15 days,IFN-γ secretion level of canines in the group of glucoside peptide injection and the group of glucoside peptide injection combined with pentavalent vaccine was higher than canines in the group of canine 5-mixed vaccines(P<0.05).This explained that glucoside peptide injection possessed the action of intensifying immunity.The results showed that glucoside peptide injection can induce IFN-γ so as to play its role of cell immunity enhancement.

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