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当前位置: 首页 > 文章 > γ-氨基丁酸对热应激大鼠新生子代的发育及抗氧化力的影响 中国农学通报 2012,28 (11) 89-92
Position: Home > Articles > Effects of γ-aminobutyric Acid on Development and Antioxidant Ability of Neonates of Heat-Stressed Rats Chinese Agricultural Science Bulletin 2012,28 (11) 89-92

γ-氨基丁酸对热应激大鼠新生子代的发育及抗氧化力的影响

作  者：
范志勇;邓近平;杨玲媛;朱立涛;杨丹丹
单  位：
湖南农业大学饲料安全与高效利用教育部工程研究中心
关键词：
γ-氨基丁酸;热应激;新生大鼠;发育;抗氧化力
摘  要：
为研究日粮中添加γ-氨基丁酸对热应激大鼠子代发育和抗氧化功能的影响。选用90日龄的Sprague-Dawley大鼠52只(雌性大鼠39只,雄性13只)进行试验,交配后27只受孕雌鼠随机分为三组,正常对照组,热应激组和GABA热应激组,仔鼠出生后1天,测定发育指标和肝脏抗氧化指标。结果显示:与正常对照组相比,热应激组新生雌鼠和雄鼠的尾长均显著降低(P<0.01);新生大鼠的肝脏谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性有所降低,丙二醛(MDA)含量有所升高,但差异均不显著。与热应激组相比,GABA热应激组新生雌鼠(P<0.01)和雄鼠(P<0.05)的尾长均显著提高;新生大鼠的肝脏MDA含量有所降低,GSH-Px、SOD活性有所升高,但差异均不显著。结果提示GABA一定程度上可改善孕期热应激条件下新生大鼠的抗应激能力。
译  名：
Effects of γ-aminobutyric Acid on Development and Antioxidant Ability of Neonates of Heat-Stressed Rats
作  者：
Fan Zhiyong 1,2,3,Deng Jinping 1,3,Yang Lingyuan 1,3,Zhu Litao 1,3,Yang Dandan 1,3 (1 Engineering Research Center for Feed Safety and Efficient Utilization of Ministry of Education Hunan Agricultural University,Changsha 410128;2 National Research center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural University,Changsha 410128;3 Institute of Animal Nutrition Hunan Agricultural University,Changsha 410128)
关键词：
γ-aminobutyric acid;heat stress;neonatal rats;development;antioxidant ability
摘  要：
The effects of dietary γ-aminobutyric acid (GABA) on development and antioxidant ability of neonates of heat-stressed rats were investigated.52 rats aged 90 days,39 females and 13 males,were the experimental subjects.27 pregnant rats were randomly divided into three groups after mating:the control group,the heat-stressed group and the GABA heat-stressed group.The development indiced and hepatic antioxidant indices of 1 d neonates were measured.The results showed that tail lengths of the female and male neonates from the heat-stressed group fed with basal diet were both decreased very significantly (P < 0.01) compared with that of the control group,while the hepatic malondialdehyde (MDA) contents increased slightly,activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) decreased slightly.Compared with the heat-stressed pregnant rats fed with basal diet,tail lengths of the female (P < 0.01)and male (P < 0.05) neonates from the GABA group,but MDA contents decreased slightly and activities of GSH-Px,SOD increased slightly.The results indicated that GABA could improve anti-heat-stress ability in neonatal rats under heat stress condition during pregnancy.

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