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Position: Home > Articles > Total Antioxidant Capacity and Protective Effect of Extract from Hairy Roots of Glycyrrhiza uralensis Fisch on CCl_4-induced Acute Liver Injury in Mice FOOD SCIENCE 2009,30 (23) 432-435

小鼠中甘草毛状根、甘草切片总抗氧化能力和对CCl_4致肝损伤保护的比较研究

作  者:
谢丽琼;李海芳;迪里
单  位:
新疆大学生命科学与技术学院;新疆维吾尔自治区药品检验所
关键词:
甘草;甘草毛状根;急性肝损伤;抗氧化
摘  要:
研究比较甘草毛状根、甘草切片提取物总抗氧化能力和CCl4引起小鼠肝脏氧化损伤的保护作用。采用CCl4(1500mg/kg·d)腹腔注射造成小鼠急性肝脏损伤模型,喂饲小鼠1周,观察其对血清AIT、AST和ALP及肝脏总抗氧化能力MDA和SOD的影响。高效液相色谱法测定甘草毛状根、甘草切片中甘草酸的含量。结果表明,与模型组相比,甘草毛状根有一定的抗脂质过氧化能力,各项抗氧化指标与对照组相比有显著性差异。甘草切片可显著逆转小鼠血清中谷草转氨酶(AST)与谷丙转氨酶(ALT)水平,而甘草毛状根没有显示出该种作用。甘草毛状根对CCl4引起的小鼠肝脏氧化损伤具有保护作用。
译  名:
Total Antioxidant Capacity and Protective Effect of Extract from Hairy Roots of Glycyrrhiza uralensis Fisch on CCl_4-induced Acute Liver Injury in Mice
作  者:
XIE Li-qiong1,LI Hai-fang2,Deliluer2 (1. College of Life Science and Technology, Xinjiang University, Urumqi 830046, China ; 2. Xinjiang Institute for Drug Control, Urumqi 830001, China)
关键词:
Glycyrrhiza uralensis Fisch;hairy roots of Glycyrrhiza uralensis Fisch;carbon tetrachloride-induced acute liver injury;antioxidant capacity
摘  要:
Total antioxidant capacity and protective effect of extract from hairy roots of Glycyrrhiza uralensis Fisch (EHRG) on CCl4-induced acute liver injury in mice were evaluated, using extract from decoction pieces of G.uralensis F (EDPG) as positive control. Results showed that SOD, MDA and T-AOC level in EHRG-treated were significantly better than those in the model group, and similar to those in positive control group. EHRG treatment exhibited little effect on AST, ALT level, while EDPG did. EHRG reduced the LDH level, as the EDPG did, compared to the model group. Pathological section showed that both EHRG and EDPG exhibited protective effect on the injury of live.

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