作 者：
杜蓉;王晓洁;阮新;刘新生;曲彦清;杨立红;肖颜颜;高红月
单 位：
烟台出入境检验检疫局;鲁东大学校医院;鲁东大学生命科学学院
摘 要：
目的:研究富锗大麦苗对四氯化碳(CCl4)所致小鼠急性肝损伤的保护作用。方法:建立CCl4小鼠急性肝损伤动物模型,用不同剂量富锗大麦苗对小鼠灌胃,测定小鼠血清谷丙转氨酶(ALT)活性及免疫器官重量等指标,对其进行统计分析,并对小鼠肝脏进行组织切片观察。结果:富锗大麦苗低、中、高剂量组均能显著抑制CCl4所致急性肝损伤小鼠ALT活性的升高(P<0.05,P<0.01),明显改善肝组织损伤程度,并与其剂量呈正相关;富锗低、中、高剂量组具有明显提高肝脏指数(P<0.01)和脾脏指数的作用(P<0.01,P<0.05)。结论:富锗大麦苗对CCl4所致小鼠急性肝损伤有明显的保护作用。
译 名：
Hepatoprotective Function of Germanium-rich Barley Seedling in Mice with Acute Hepatic Injury
作 者：
DU Rong1,WANG Xiao-jie1,RUAN Xin2,LIU Xin-sheng3,QU Yan-qing3,YANG Li-hong1, XIAO Yan-yan1,GAO Hong-yue1 (1. College of Life Science, Ludong University, Yantai 264025, China;2. Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000,China;3. College of Hospital, Ludong University, Yantai 264025, China)
关键词：
germanium-rich barley seedling;CCl4;acute hepatic injury;mice
摘 要：
Objective: To investigate hepatoprotective effect of germanium-rich barley seedling (GRBS) in mice with acute hepatic injury induced by CCl4. Methods: Mice model with acute hepatic injury was established through induction of CCl4. The mice with acute hepatic injury were orally administered GRBS at different doses (low, medium and high-doses). ALT activity in serum and immune organs index were determined and pathological changes of livers were examined to evaluate the hepatoprotective effect of GRBS. Results: GRBS at three doses significantly inhibited ALT activity in serum (P < 0.05, P < 0.01) and promoted the recovery of hepatic tissue injury, which was in a dose-dependent mode. Moreover, GRBS also obviously improved liver index (P < 0.01) and spleen index (P < 0.01, P < 0.05). Conclusion: GRBS has hepatoprotective function for mice with acute hepatic injury induced by CCl4.
