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当前位置: 首页 > 文章 > 饲料中添加“健肝散”预防丁脂肪肝的作用 水生态学杂志 2010,03 (3) 97-101
Position: Home > Articles > Effects of Diet-supplemental"Jiangansan"on Fatty Liver Pathological Changes in Tincaeus(Tinca tinca) Journal of Hydroecology 2010,03 (3) 97-101

饲料中添加“健肝散”预防丁脂肪肝的作用

作  者：
张盈娇;谢青;曾晓丹;杜娟;夏陈;王自鹏;钟振东
单  位：
四川省农业科学院水产用兽药临床药效及残留试验中心;成都中医药大学;四川省医学科学院·四川省人民医院试验动物研究所;四川省兽药监察所
关键词：
中草药;丁;脂肪肝
摘  要：
研究了在饲料中添加"健肝散"预防丁(Tinca tinca)脂肪肝的作用。采用"健肝散"添加量分别为0.1%、0.2%、0.4%的饲料进行丁养殖试验,试验周期为40d,观察"健肝散"对其生长指标、血清主要生理、生化指标的影响。结果表明,当"健肝散"添加量为0.4%时,丁的增重率、相对生长率和高密度脂蛋白胆固醇最高,肝脏脂肪含量最低,与空白对照组相比有显著差异(P<0.05),与氯化胆碱组均无显著差异(P>0.05);血浆中胆固醇、甘油三酯含量最高,与空白对照组相比有显著差异(P<0.05),与氯化胆碱组有显著差异(P<0.05);谷丙转氨酶、谷草转氨酶、乳酸脱氢酶的活性较低,与空白对照组相比有显著差异(P<0.05),其中乳酸脱氢酶的活性显著低于氯化胆碱组(P<0.05)。当"健肝散"添加量为0.2%和0.4%时,肝体比均较低,与空白对照组相比有显著差异(P<0.05),与氯化胆碱组无显著差异(P>0.05);添加量为0.1%、0.2%和0.4%时,低密度脂蛋白胆固醇均较高,与空白对照组相比有显著差异(P<0.05),与氯化胆碱组无显著差异(P>0.05)。在本研究条件下,丁饲料中添加0.4%的"健肝散"时,可有效预防其脂肪肝疾病。
译  名：
Effects of Diet-supplemental"Jiangansan"on Fatty Liver Pathological Changes in Tincaeus(Tinca tinca)
作  者：
ZHANG Ying-jiao1,XIE qing2,ZENG Xiao-dan1,DU Juan3,XIA Chen1, WANG Zi-peng1,ZHONG Zheng-dong4 (1. Sichuan Academy of Agricultural Sciences,Chengdu 610066,China; 2. Sichuan Provincial Institute for Veterinary Drug Control,Chengdu 610041,China; 3. Chengdu University of TCM,Chengdu 610075,China; 4. Department of pharmaceutical non-clinical study,Institute of Laboratory Animals of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital,Chengdu 610072,China)
关键词：
Chinese herbs; Tinca tinca;Fatty live
摘  要：
To observe the preventative effect of"Jiangansan"on fatty liver pathological changes in Tincaeus(Tinca tinca). This experiment was conducted to evaluate the effects of dietary "Jiangansan"levels on growth,HSI,liver fat content and several biochemical indexes in hepatopancreas,and plasma related to fatty liver pathological change. Tincaeus were fed with three levels of supplemental"Jiangansan"(0. 1% ,0. 2% ,0. 4% )for 40d. The results indicated that as the"Jiangansan"supplement was 0. 4% diet,the weight gain rate,the relative growth rate and the concentrations of HDL-C in blood plasma were achieving the peak values,liver fat content dropped to the bottom,but insignificantly different from those in the positive control group(P > 0. 05);and the concentrations of CHOL,TG in blood plasma were all increased obviously,and significantly different from those in the positive control group(P < 0. 05);The activities of ALT,AST and LDH were all at the lowest value,and The activities of LDH was lower significantly than in the positive control group(P < 0. 05). When the "Jiangansan"supplement were 0. 2% and 0. 4% , liver weight/body weight ratio(HS) were all decreased obviously,but insignificantly different from those in the positive control group(P > 0. 05). When the "Jiangansan"supplement were 0. 1% ,0. 2% ,0. 4% ,the concentrations of LDL-C in blood plasma were all at high value,but insignificantly different from those in the positive control group (P >0. 05). Therefore,under this research condition,it is suggested that the supplement of"Jiangansan"in diets of Tincaeus (Tinca tinca) was the best at 0. 4% diet,and it can effectively prevent fatty liver.

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