中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 葛根素及葛根异黄酮对小鼠急性醉酒预防和解酒效果的研究 食品科学 2014,35 (15) 247-250
Position: Home > Articles > Puerarin and Isofl avones from Kudzu Root(Pueraria lobata Ohwi) Prevent Acute Drunkenness and Relieve Alcoholism in Mice FOOD SCIENCE 2014,35 (15) 247-250

葛根素及葛根异黄酮对小鼠急性醉酒预防和解酒效果的研究

作  者：
朱振元;薛婧;刘晓翠;孟梦;唐亚丽;张军;郭蓉
单  位：
食品营养与安全教育部重点实验室;食品营养与安全教育部重点实验室,天津科技大学食品工程与生物技术学院
关键词：
葛根素;葛根异黄酮;小鼠;急性解酒防醉;醉酒时间;醒酒时间
摘  要：
目的 :研究葛根素及葛根异黄酮对小鼠急性防醉解酒的效果。方法:将小鼠随机分成5组,标记为对照组、葛根粗提物组、葛根异黄酮组、60%葛根素组、99%葛根素组。禁食(不禁水)1 2 h后,每组灌胃等剂量的对应物50%丙二醇水溶液(对照组灌胃50%丙二醇水溶液),30 min后灌胃等剂量56°红星二锅头,观察其醉酒时间与醒酒时间以研究不同含量葛根素对小鼠急性防醉解酒的效果,并在给酒后持续检测小鼠血液中的乙醇含量,以表征不同时段小鼠的醉酒程度。将另一批小鼠随机分为4组,禁食(不禁水)12 h后,分别按100、200、300、400 mg/kg(以体质量计,葛根异黄酮中葛根素含量约为22.13%)剂量灌胃,醉酒时间与醒酒时间以研究葛根素防醉解酒的最佳给药量。结果:随着所给药物中葛根素含量的增高,小鼠急性醉酒的醉酒时间逐渐延长,醒酒时间逐渐缩短。随着葛根素含量的增高,药品解酒防醉的效果越好,但在300 mg/kg(以体质量计)之后,变化趋于缓和。结论:葛根素对小鼠急性防醉解酒有较好的预防效果,葛根中其他异黄酮类物质与葛根素有相似的防醉解酒功效。
译  名：
Puerarin and Isofl avones from Kudzu Root(Pueraria lobata Ohwi) Prevent Acute Drunkenness and Relieve Alcoholism in Mice
作  者：
ZHU Zhen-yuan;XUE Jing;LIU Xiao-cui;MENG Meng;TANG Ya-li;ZHANG Jun;GUO Rong;Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology,Tianjin University of Science and Technology;
关键词：
puerarin;;kudzu root isoflavones;;mice;;anti-drunk;;drunk time;;sober-up time
摘  要：
Objective: The present study aimed to evaluate the effects of puerarin and isofl avones from kudzu root(Pueraria lobata Ohwi) on preventing acute drunkenness and relieving alcoholism in mice. Method: Firstly, mice were divided randomly into five groups: control, crude kudzu root extract, kudzu root isoflavone, 60% puerarin, and 99% puerarin. After 12 hours of fasting but with access to water, the mice in each group were orally administered with an equal dose of the corresponding materials in 50% aqueous propylene glycol solution(the solvent alone for the control group). After 30 minutes, the mice from each group were administered by gavage with an identical volume of 56° red star Erguotou liquor. The preventive effect of different contents of puerarin on acute drunkenness was investigated by observing the drunk time and sober-up time. At the sam e time, the ethanol concentration in blood samples of mice was continuously detected to characterize the degree of intoxication in mice at different time points. Secondly, another batch of mice were divided into four groups, which were administered with kudzu root isofl avone containing approximately 22.13% puerarin at doses of 100, 200, 300 and 400 mg/kg bw after 12 hours of fasting with access to water, respectively. The optimal dose for preventing acute drunkenness and relieving alcoholism was selected based on the drunk time and sober-up time. Results: With increasing amount of puerarin in the materials administered to mice, the drunk time was increased and sober-up time was shortened. Hence, the effect of puerarin is positively proportional to its content. However, no obvious change was observed when the puerarin content exceeded 300 mg/kg bw. Conclusion: Puerarin is effective at preventing acute drunkenness and relieving alcoholism. Other isofl avones from kudzu root have similar effect to that of puerarin.

相似文章

导出引用
计量
文章访问数: 7
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46