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唑草酮的合成

作  者:
李梅芳;韩邦友
单  位:
江苏快达农化股份有限公司
关键词:
唑草酮;三唑啉酮;合成路线;制备
摘  要:
改进了除草剂唑草酮的合成工艺,以4-氯-2-氟苯肼为原料,经氨基腙合成、光气环合制成取代芳基三唑啉酮,再经二氟甲基化、硝化、加氢还原合成中间体1-(5-氨基-4-氯-2-氟苯基)-3-甲基-4-二氟甲基-1H-1,2,4-三唑啉-5-酮,重氮化后与丙烯酸乙酯反应,经后处理得唑草酮。
译  名:
Synthesis Process of Carfentrazone-ethyl
作  者:
LI Mei-fang,HAN Bang-you(Jiangsu Kuaida Agrochemical Co.,Ltd.,Jiangsu Rudong 226401,China)
关键词:
carfentrazone-ethyl;triazolinones;synthesis route;preparation
摘  要:
The synthesis process of carfentrazone-ethyl was greatly improved.Using 4-chloro-2-fluorophenylhydrazine as the raw material,substitutional aryl-triazolinones was prepared by synthesis of amidrazone and phosgene cyclization.Then intermediate product 1-(5-amino-4-chloro-2-fluorophenyl)-3-methyl-4-difluoromethyl-1H-1,2,4-triazole-5-one was got through difluoromethylation and nitration and hydrogenating reduction.By means of the process of diazotization and then reacting with ethyl acrylate,carfentrazone-ethyl was finally obtained.

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