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当前位置: 首页 > 文章 > H9N2亚型流感病毒野鸟分离株HA受体亲和特性鉴定及基因序列分析 吉林农业大学学报 2019 (4) 477-482
Position: Home > Articles > HA Receptor Affinity Identification and Gene Sequence Analysis of H9N2 Subtype AIV Strains Isolated from Wild Birds Journal of Jilin Agricultural University 2019 (4) 477-482

H9N2亚型流感病毒野鸟分离株HA受体亲和特性鉴定及基因序列分析

关键词：
流感病毒;H9N2亚型;HA;序列分析;受体结合位点;跨种传播
摘  要：
为了解H9N2亚型流感毒株的变异及跨种间传播机制,通过基因序列测定和固相酶联试验对2016—2017年吉林地区的8株H9N2亚型流感病毒野鸟分离株的HA氨基酸序列及HA的受体结合特性进行了分析。结果表明:8株病毒均具有与人型受体和禽型受体结合特性,其中3株病毒HA的226位氨基酸为L,病毒则偏嗜结合6'SL即人型受体,其余5株病毒HA的226位氨基酸为Q,病毒偏嗜结合3'SL即禽型受体,这暗示着H9N2亚型病毒存在着感染人的潜能,因此应密切监测野鸟H9N2亚型流感病毒的流行特征,为动物及人间流感的防控提供参考。
译  名：
HA Receptor Affinity Identification and Gene Sequence Analysis of H9N2 Subtype AIV Strains Isolated from Wild Birds
作  者：
LIU Mengdi;YAO Guizhe;YANG Fan;MENG Qingfeng;CONG Yanlong;WANG Wei-li;LI Yue;College of Animal Science and Technology,Jilin Agricultural University;Jilin Entry-Exit Inspection and Quarantine Bureau;College of Veterinary Medicine,Jilin University;
关键词：
influenza virus;;H9N2 subtype;;HA;;sequence analysis;;receptor binding site;;interspecies transmission
摘  要：
In order to understand the variation and the mechanism of cross-species transmission mechanism of influenza subtype strains,we analyzed the HA sequence and receptor affinity of 8 H9 N2 strains isolated from wild birds in Jilin province from 2016 to 2017 through gene sequence analysis and ELISA. The results showed that all the 8 strains had binding ability to both human type receptor and avian type receptor. Among them,HA 226 amino acid of 3 strains of virus is L,in which case the virus is biased to combine 6'SL-type receptor,namely human receptor. In the remaining 5 strains,HA 226 amino acid is Q,which is biased to bind 3' SL-bird-type receptor. The results suggests that the influenza virus has the potential to infect human beings,posing the importance of molecular epidemiological investigation of influenza subtype influenza virus and providing the basis for the prevention and control of human influenza.

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