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当前位置: 首页 > 文章 > 槲皮素及其乙酸乙酯衍生物的平衡溶解度和油水分配系数的测定 食品科学 2015,36 (14) 55-58
Position: Home > Articles > Determination of Equilibrium Solubility and Apparent Oil/Water Partition Coefficients of Quercetin and Its Ethyl Acetate Derivatives FOOD SCIENCE 2015,36 (14) 55-58

槲皮素及其乙酸乙酯衍生物的平衡溶解度和油水分配系数的测定

作  者：
何翊;秦燕;范亚苇;邓泽元;胡蒋宁
单  位：
南昌大学食品科学与技术国家重点实验室
关键词：
槲皮素;3,7,3’,4’-O-四乙酸乙酯槲皮素;平衡溶解度;油水分配系数
摘  要：
通过测定槲皮素及其酯化物的平衡溶解度和油水分配系数,检测酯化后的槲皮素衍生物脂溶性是否提高。采用高效液相色谱法测定槲皮素及3,7,3’,4’-O-四乙酸乙酯槲皮素在水、不同缓冲盐溶液中的质量浓度;采用摇瓶-液相色谱法,测定二者在正辛醇-水、缓冲液体系中的油水分配系数。37℃时,槲皮素在水中的平衡溶解度为23.02μg/m L,而3,7,3’,4’-O-四乙酸乙酯槲皮素在水中的平衡溶解度更小,为10.23μg/m L。随着溶剂p H值的增大,槲皮素的平衡溶解度增大,3,7,3’,4’-O-四乙酸乙酯槲皮素变化并不显著。槲皮素、3,7,3’,4’-O-四乙酸乙酯槲皮素在正辛醇-水体系条件下的油水分配系数分别为1.819、3.696。酯化修饰后的3,7,3’,4’-O-四乙酸乙酯槲皮素脂溶性高于槲皮素。
译  名：
Determination of Equilibrium Solubility and Apparent Oil/Water Partition Coefficients of Quercetin and Its Ethyl Acetate Derivatives
作  者：
HE Yi;QIN Yan;FAN Yawei;DENG Zeyuan;HU Jiangning;State Key Laboratory of Food Science and Technology, Nanchang University;
关键词：
querctin;;ethyl acetate derivative of quercetin;;equilibrium solubility;;apparent oil/water partition coefficient
摘  要：
This study aimed to determine the equilibrium solubility and oil/water partition coefficients of quercetin and its ester derivative. The equilibrium solutions of quercetin and its ethyl acetate derivative in various media were detected by high performance liquid chromatogram(HPLC); and the shake flask-HPLC method was applied to determine the partition coefficients of quercetin and its ethyl acetate derivative in n-octanol-water-buffer solutions of different p H values. The equilibrium solubility of querctin and its ethyl acetate derivative was 23.02 and 10.23 μg/m L in water at 37 ℃, and the equilibrium solubility of querctin increased with increasing p H of the buffer solution, but no remarkable change was observed for its ethyl acetate derivative. The partition coefficients of quercetin and its ethyl acetate derivative in n-octanolwater-buffer solutions of different p H were 1.819 and 3.696, respectively. The esterification modification of quercetin improved its lipid solubility.

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