当前位置: 首页 > 文章 > 甲基睾酮对小鼠的急性毒性试验 云南农业大学学报(自然科学) 2015,30 (1) 151-153
Position: Home > Articles > Acute Toxicity Experiments of 17-methyltestosterone on Mice Journal of Yunnan Agricultural University(Natural Science) 2015,30 (1) 151-153

甲基睾酮对小鼠的急性毒性试验

作  者:
王轶;施瀚超;刘文文;代佳和;徐昆龙
单  位:
云南农业大学动物科学技术学院
关键词:
甲基睾酮;小鼠;急性毒性;半数致死量(LD50)
摘  要:
为初步了解甲基睾酮的安全性,用昆明种(系)小鼠进行甲基睾酮的急性毒性试验。试验测定绝对致死量(LD100)为4 500.0 mg/kg,最大耐受剂量(LD0)为1 499.7 mg/kg;测定甲基睾酮对昆明种小鼠的半数致死量(LD50)为2 879.7 mg/kg,LD50的95%可信限为2 522.3~3 287.6 mg/kg。根据外源性化学物的急性毒性分级标准,甲基睾酮对昆明种小鼠有低毒性。
译  名:
Acute Toxicity Experiments of 17-methyltestosterone on Mice
作  者:
WANG Yi;SHI Hanchao;LIU Wenwen;DAI Jiahe;XU Kunlong;College of Animal Science and Technology,Yunnan Agricultural University;
关键词:
17-methyltestosterone;;mice;;the acute toxicity experiments;;median lethal dose(LD50)
摘  要:
In order to investigate the safety of 17-methyltestosterone,Kunming mice were tested for its acute toxicity. The absolutely lethal dose( LD100) was determined 4 500. 0 mg per kilogram body weight,and the maximum tolerated dose( LD0) was 1 499. 7 mg per kilogram body weight in the preexperiments. In the formal experiment,median lethal dose( LD50) of methyltestosterone in Kunming mice was determined 2 879. 7 mg per kilogram body weight,and the 95% confidence limit was2 522. 3 ~ 3 287. 6 mg / kg body weight. According to acute toxicity grading on exogenous chemicals,methyltestosterone has low toxicity in Kunming mice.

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