Effects of ω-3 Fish Oil Fat Emulsion on Respiratory System Inflammation in Critically Ill Patients

FAN Rong;LIU Jun;ZOU Jie;DU Shan-shan;LI Li;ZHU Wen-yi;HUANG Chen;WANG Jian;Department of Nutrition,Xinqiao Hospital,the Third Military Medical University;

ω-3 fish oil fat emulsion;;nutritional support;;inflammation;;respiratory system;;critical care

【Objective】To investigate the influence of ω-3 fatty acids fish oil fat emulsion on the respiratory system inflammation in critically ill patients to provide the basis for clinical treatment.【Method】Totally 55 respiratory critically ill patients in Xinqiao Hospital ICU with IMV were erolled,the test group had 26 patients,the control group had 29 patients.In addition to adopt conventional treatment.All the patients were assigned to receive a isonitrogenic and isocalorie nutritional support,energy 30 kcal/(kg·d) and protein 1.2g/(kg·d),which was enteral nutrition combined with parenteral nutrition.Patients in study group were treated with Enteral nutrition combined with adding ω-3 fatty acids,fish oil fat emulsion parenteral nutritional support,the control group patients,who used enteral nutrition combined with Parenteral nutritional support without ω-3 fatty acids in fish oil fat emulsion.Extracting peripheral blood of the two groups of patients before using the nutritional support 1 day and after 6 days,and measuring inflammation indicators:C-reactive protein(CRP) levels was detcted by turbidimetric inhibition immuno assay,tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) levels was by Chemi Luminescence.At the same time we recorded the length of ICU stay and the duration of mechanical ventilation.【Result】Before nutritional supported there were no significant different of CRP,TNF-α,IL-6(P > 0.05) between test group and control group,but after nutritional supported6 days,all the inflammation indicators of the study group patients decreased,and compared with two groups results showed that the levels of serum CRP,TNF-α,IL-6 were significant difference(P < 0.05),the test group was significantly lower than the control group.The duration of mechanical ventilation was significantly different from the control group(P < 0.05).The length of ICU was not significantly different between two groups(P > 0.05).【Conclusion】ω-3 fatty acids fish oil fat emulsion can improve respiratory system inflammation in critically ill patients,which is benefical for hort the duration of mechanical ventilation.