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当前位置: 首页 > 文章 > 吡喹酮非水溶液注射剂的研制——日本血吸虫病治疗试验 中国兽医学报 2003,23 (4) 353-355
Position: Home > Articles > The Development of Praziquantel Injection——Study on the Treatment of Schistosomiasis Japonicum Chinese Journal of Veterinary Science 2003,23 (4) 353-355

吡喹酮非水溶液注射剂的研制——日本血吸虫病治疗试验

作  者：
赵俊龙;刘恩勇;李克斌;姚宝安;程方玺;吴海青;操继跃;周艳琴
单  位：
随州市畜牧局;湖北省动物血防站;华中农业大学畜牧兽医学院
关键词：
日本血吸虫病;吡喹酮注射剂;牛
摘  要：
利用本课题组研制的吡喹酮非水溶液注射剂 ,分别进行了小鼠和牛的日本血吸虫病治疗试验。结果表明 ,感染日本血吸虫的小鼠按每千克体质量 2 0 mg和 30 mg的剂量肌肉注射吡喹酮的减雌率均达 10 0 % ,人工感染日本血吸虫的牛按每千克体质量 10 mg和 12 mg的剂量肌肉注射吡喹酮的减雌率均达 10 0 % ,每千克体质量 8m g的剂量的减雌率为 96 .4 1%。自然感染血吸虫病牛按每千克体质量 10 mg的剂量肌肉注射后 30 d,粪便转阴率达 90 .5 0 %。这一结果说明 ,研制的吡喹酮注射剂具有良好的治疗效果
译  名：
The Development of Praziquantel Injection——Study on the Treatment of Schistosomiasis Japonicum
作  者：
ZHAO Jun long 1,LIU En yong 2,LI Ke bin 2,YAO Bao an 1,CHENG Fang xi 3,WU Hai qing 3, CAO Ji yue 1,ZHOU Yan qin 1 (1.College of Animal Science and Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China;2.Institute of Schistosomiasis Control of Hubei Province, Wuhan 430064,China;3.Animal Husbandry Bureau of Shuizhou City,Shuizhou, Hubei 434000,China)
关键词：
schistosomiasis japonicum; praziquantel injection; cattle
摘  要：
The treatment test of mice and cattle schistosomiasis japonicum by praziquantel injection were carried out.The results showed that:mice infected with Schistosoma japonicum were intramusularly administrated with praziquantel at a dose of 20,30 mg/kg bodyweight,all mice were autopsied one month after treatment,all of the two groups got 100% female reduction rate;artificial infested cattle were intramuscularly adiministrated with praziquantel at a dose of 8,10,12 mg/kg bodyweight,all cattle were autopsied 20 days after treatment,the female reduction rates of the group at dose of 8 mg/kg bodyweight were 96 41%,the female reduction rates of the other group were all 100%;natural infested cattle were intramuscularly adiministrated with praziquantel at a dose of 10 mg/kg bodyweight,the retro negative rate was 90 50% thirty days after treatment.

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