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当前位置: 首页 > 文章 > 氟甲砜霉素对鸭疫里氏杆菌病的药效学研究 江西农业大学学报 2004,26 (4) 107-109
Position: Home > Articles > The Pharmacodynamics of Florfenical in Experimental InfectedDucklings with Riemerella anatipestifer Acta Agriculturae Universitatis Jiangxiensis 2004,26 (4) 107-109

氟甲砜霉素对鸭疫里氏杆菌病的药效学研究

作  者：
王小莺;何后军
单  位：
江西农业大学动物科学技术学院
关键词：
氟甲砜霉素;鸭疫里氏杆菌;药效学
摘  要：
以试管二倍稀释法测定了氟甲砜霉素、氯霉素、红霉素、林可霉素、SMZ、氟哌酸对鸭疫里氏杆菌的体外最小抑菌浓度88.1为1μg/mL、2μg/mL、4μg/mL、32μg/mL、64μg/mL、8μg/mL。180只健康本地麻鸭分成6组,每组30只,除1组作健康对照外,其它5组按2.5mL/kg.bw皮下注射鸭疫里氏杆菌培养物(3.8×109cfu/mL)。感染鸭用氟甲砜霉素内服治疗,给药剂量分别为30mg/kg、20mg/kg、10mg/kg,以氯霉素作对照(30mg/kg),1d1次,连续用药3d,给药结束15d后,各治疗组的治愈率为93.3%,90.0%,80.7%和82.1%,感染对照组死亡率为56.7%。
译  名：
The Pharmacodynamics of Florfenical in Experimental InfectedDucklings with Riemerella anatipestifer
作  者：
WANG Xiao-ying, HE Hou-jun(College of Animal Science and Technology, JAU, Nanchang 330045, China)
关键词：
florfenical;Rimerella Anatipestifer(RA);pharmacodynamics
摘  要：
The studies included the determination of minimal inhibitory concentrations (MICs)of florfenical, chlorenfenical, erythromycin, linkemycin, SMZ and norfloxacin against Riemerella anatipestifer(RA) in vitro.The MICs of them against RA were 1μg/mL, 2μg/mL, 4μg/mL, 32μg/mL, 64μg/mL, 8μg/mL, respectively. One hundred and eighty ducklings aged two weeks were randomly assigned to six groups, 30 ducklings for each group. One of the 6 groups was used as uninfected and untreated group. Each duckling in the 5 groups was infected hypodermic injection(2.5 mL/kg·bw) with RA. Three groups of the infected ducklings were treated with florfenical orally at the dosage of 10 mg/kg, 20 mg/kg, 30 mg/kg, respectively. One group of the infected ducklings were treated with chloramfenical as the positive control at a dosage of 30 mg/kg·bw following oral administration. Fifteen days after the final medication, the curative rates of the florfenical-treated groups and the positive control group were 93.3%, 90.0%, 80.7%, 82.1%, respectively. The mortalily rate of the negative control group was 56.7%.

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