Position: Home > Articles > Research Progress on Antiviral Effect of MDA5 in Innate Immunity
China Animal Husbandry & Veterinary Medicine
2015,42
(1)
230-233
MDA5在先天性免疫抗病毒作用中的研究进展
作 者：
刘欢欢;谢丽君;邵志勇;高洪;严玉霖
单 位：
云南农业大学动物科学技术学院
关键词：
黑色素瘤分化相关基因5(MDA5);接头蛋白;磷酸化;Ⅰ型干扰素
摘 要：
黑色素瘤分化相关基因5(melanoma differentiation-associated gene-5,MDA5)是胞浆内核酸受体,与病原相关分子模式(pathogen-associated molecular patterns,PAMPs)相结合,特异性地识别较长的双链RNA,功能与视黄酸诱导表达基因Ⅰ(retinoic acid-inducude geneⅠ,RIG-Ⅰ)相似,通过自身级联激活和招募结构域(CARD)与接头蛋白CARD同源相互作用之后,与接头蛋白线粒体连接蛋白(MAVS)(也叫VISA、Cardif或IPS-1)结合,相互作用后会导致RIG-Ⅰ样受体(RLR)在内膜上重新定位,一边招募来TRAF2/TRAF6活化IKK激酶复合物,从而激活转录因子NF-κB;另一边招募来TRAF3和TBK1,从而促进IRF3的磷酸化激活,活化后的转录因子NF-κB及IRF会进入细胞核,共同协作促进Ⅰ型干扰素基因的表达。
译 名：
Research Progress on Antiviral Effect of MDA5 in Innate Immunity
作 者：
LIU Huan-huan;XIE Li-jun;SHAO Zhi-yong;GAO Hong;YAN Yu-lin;College of Animal Science and Technology,Yunnan Agricultural University;
关键词：
MDA5;;adaptor protein;;phosphorylation;;typeⅠinterferon
摘 要：
Melanoma differentiation-associated gene-5(MDA5)was a nucleic acid receptor in the cytoplasm,in combination with pathogen-associated molecular patterns(PAMPs),which specifically recognized a long double-stranded RNA,function was similar with retinoic acid-inducude geneⅠ(RIG-Ⅰ),after CARD-CARD interaction,it was combinated with the adaptor protein MAVS(also called VISA,Cardif or IPS-1),the interaction might result in the reposition of RLRs in intima,one side it recruited TRAF2/TRAF6 to activate IKK kinase complexes,thereby activating the transcription factor NF-κB;on the other side it recruited TRAF3 and TBK1,thereby promoting phosphorylated activation of IRF3,after activations of the transcription factor NF-κB and IRF,they would enter the nucleus,and work together to promote the expression of typeⅠ interferon gene.
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