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当前位置: 首页 > 文章 > 槲皮素与6-O-α-D-麦芽糖-β-环糊精包合物的理化表征 食品科学 2016,37 (21) 38-42
Position: Home > Articles > Physicochemical Properties of Inclusion Complex of Quercetin with 6-O-α-D-Maltosyl-β-Cyclodextrin FOOD SCIENCE 2016,37 (21) 38-42

槲皮素与6-O-α-D-麦芽糖-β-环糊精包合物的理化表征

作  者：
李赟;汪芳;邹伟;王雪松;蔡红燕;陈轩;孙威;沈汪洋
单  位：
武汉凯迪工程技术研究总院有限公司;武汉轻工大学食品科学与工程学院
关键词：
槲皮素;6-O-α-D-麦芽糖-β-环糊精;包合物;理化性质;分子对接
摘  要：
采用相溶解度法研究6-O-α-D-麦芽糖-β-环糊精(6-O-α-D-maltosyl-β-cyclodextrin,Mal-β-CD)和β-环糊精(β-cyclodextrin,β-CD)对槲皮素的包合效果,利用溶剂法制备Mal-β-CD与槲皮素的包合物,借助紫外光谱分析、红外光谱分析、扫描电子显微镜、X射线衍射、热重及差示扫描量热联用等分析手段研究该包合物的理化性质,并采用分子对接法建立了该包合物的超分子结构。结果表明:Mal-β-CD包合槲皮素的能力高于母体β-CD。分子对接结果表明,槲皮素是沿Mal-β-CD的大口端方向进入其疏水空腔形成包合物,二者间是通过氢键相连接的。较之母体β-CD,Mal-β-CD与槲皮素的包合效果更好,且包合后槲皮素的物相发生重大变化,热稳定性提高。
译  名：
Physicochemical Properties of Inclusion Complex of Quercetin with 6-O-α-D-Maltosyl-β-Cyclodextrin
作  者：
LI Yun;WANG Fang;ZOU Wei;WANG Xuesong;CAI Hongyan;CHEN Xuan;SUN Wei;SHEN Wangyang;College of Food Science and Engineering, Wuhan Polytechnic University;Wuhan Kaidi General Research Institute Engineering&Technology Co.Ltd.;Key Laboratory of the Deep Processing of Bulk Grain and Oil Authorized, Ministry of Education;
关键词：
quercetin;;6-O-α-D-maltosyl-β-cyclodextrin;;inclusion complex;;physicochemical property;;molecular docking
摘  要：
In this study,the inclusion efficiency of 6-O-α-D-maltosyl-β-cyclodextrin(Mal-β-CD) and β-cyclodextrin(β-CD) for quercetin was studied by the phase solubility method,and the inclusion complex of quercetin with Mal-β-CD was prepared by the solvent method.The physicochemical properties of the inclusion complex were studied by ultravioletvisible spectroscopy,infrared spectroscopy,scanning electron microscope,X-ray diffractometry,and thermogravimetric/differential scanning calorimetry.The molecular docking method was also applied to study the three-dimensional supermolecular structure of the complex.The results showed that the inclusion efficiency of Mal-β-CD was superior to β-CD.The results of molecular docking showed that quercetin could enter the hydrophobic cavity from the wide rim of G2-β-CD to form a super-molecular structure.Quercetin and Mal-β-CD were connected by hydrogen bonds.Compared with β-CD,Mal-β-CD exhibited higher inclusion efficiency,resulting in significantly changed physicochemical properties and improved stability of quercetin.

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