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Position: Home > Articles > Research of Acute Toxicity of Shuanghuanglian Oral Liquid Chinese Journal of Veterinary Drug 2011,45 (12) 29-30+52

双黄连口服液的急性毒性试验研究

作  者:
周德刚;张晓会;刘兴金;高富红
单  位:
国家兽用药品工程技术研究中心
关键词:
双黄连口服液;小鼠;急性毒性
摘  要:
为了解双黄连口服液在使用过程中的安全性,参照《兽药注册资料汇编》中兽药急性毒性试验指导原则的要求,选用小白鼠进行急性毒性试验。小白鼠的最小致死量、半数致死量测定结果显示:双黄连口服液对小白鼠最小致死量范围为49.2~60.8 g/kg,相当于禽临床用量的111.8~138.2倍,说明双黄连口服液临床应用具有一定的安全性。
译  名:
Research of Acute Toxicity of Shuanghuanglian Oral Liquid
作  者:
ZHOU De-gang,ZHANG Xiao-hui,LIU Xing-jin,GAO Fu-hong(National Research Center for Veterinary Medicine,Luoyang,Henan 471003,China)
关键词:
Shuanghuanglian oral liquid;mouse;acute toxicity
摘  要:
In order to observe the applied reliability of Shuanghuanglian oral liquid,the experiment was conducted in accordance with acute toxicity requirements in compilation of veterinary drug registration data.The acute toxicity of Shuanghuanglian oral liquid was studied by selecting mouse in this experiment,the toxicity of Shuanghuanglian oral liquid was demonstrated by the minimal lethal dose and the LD50 of mouse.The results showed that the minimal lethal dose ranged between 49.2 and 60.8 g/kg,which was equivalent to from 111.8 to 138.2 times of daily dosage of poultry.Shuanghuanglian oral liquid was relatively safe in clinical application.

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