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当前位置: 首页 > 文章 > 不同剂量替米考星对雏鸡心脏功能和呼吸的影响 中国畜牧兽医 2011,38 (8) 214-218
Position: Home > Articles > Effect of Different Doses of Tilmicosin on Cardiac Function and Respiration of Chicken China Animal Husbandry & Veterinary Medicine 2011,38 (8) 214-218

不同剂量替米考星对雏鸡心脏功能和呼吸的影响

作  者：
利凯;张立永;马利芹;徐明举;杨永红;王杏
单  位：
河北北方学院动物科技学院
关键词：
替米考星;雏鸡;心功能;呼吸
摘  要：
本试验将70只45日龄的罗曼鸡随机分成对照组和试验Ⅰ～Ⅵ组,旨在探讨不同剂量替米考星对雏鸡心功能和呼吸的影响。结果显示,随着替米考星剂量的加大和给药时间的延长,Ⅴ组死亡2只,Ⅵ组死亡4只;心率(HR)由增加到逐渐恢复,但5h后,Ⅵ组HR极显著低于对照组(P<0.01);左心室收缩压(LVSP)和左室内压最大变化速率(±dp/dtmax)呈逐渐下降趋势,左心室舒张末压(LVEDP)则逐渐升高,给药5h后,Ⅳ、Ⅴ和Ⅵ组LVSP极显著低于对照组、Ⅰ、Ⅱ和Ⅲ组(P<0.01),Ⅴ和Ⅵ组极显著低于Ⅳ组(P<0.01)。Ⅱ组LVEDP显著高于对照组和Ⅰ组(P<0.05),Ⅲ和Ⅳ组显著高于Ⅱ组(P<0.05),极显著高于对照组和Ⅰ组(P<0.01)。Ⅴ、Ⅵ组极显著高于其他各组(P<0.01);Ⅰ～Ⅴ组呼吸逐渐加深加快。5h后,Ⅲ、Ⅳ和Ⅴ组呼吸率显著高于对照组、Ⅰ和Ⅱ组(P<0.05),但Ⅵ组呼吸率极显著低于Ⅲ、Ⅳ和Ⅴ组(P<0.01)。提示替米考星在治疗雏鸡疾病时饮水安全使用剂量为400～600mg/L,超过800mg/L时会对心肺功能产生明显影响。
译  名：
Effect of Different Doses of Tilmicosin on Cardiac Function and Respiration of Chicken
作  者：
LI Kai,ZHANG Li-yong,MA Li-qin,XU Ming-ju,YANG Yong-hong,WANG Xing(College of Animal Science,Hebei North University,Zhangjiakou 075131,China)
关键词：
Tilmicosin;chicken;cardiac function;respiratory
摘  要：
70 of the 45-day Roman chickens were randomly divided into control group and experimental Ⅰ-Ⅵ groups to explore the impact of different doses of Tilmicosin on cardiac function and respiratory.With increasing dose and administration time of Tilmicosin,the results showed that 2 died in Ⅴ group and 4 died in Ⅵ group;heart rate(HR) increased and then gradually restored.However,after 5 h,HR of Ⅵ group was significantly lower than the control group(P<0.01);left ventricular systolic pressure(LVSP) and maximum rate of change of left ventricular pressure(±dp/dtmax) decreased gradually,the left ventricular end diastolic pressure(LVEDP) is increased gradually.5 h after administration,LVSP of Ⅳ,Ⅴ and Ⅵ group was significantly lower than the control group,Ⅰ,Ⅱ and Ⅲ group(P<0.01),Ⅴ and Ⅵ group was significantly lower than group Ⅳ(P<0.01).LVEDP was significantly higher in group Ⅱ compared with the control group and Ⅰ group(P<0.05),Ⅲ and Ⅳ were significantly higher than group Ⅱ(P<0.05),and significantly higher than group Ⅰ(P<0.01).Ⅴ and Ⅵ group was significantly higher than other groups(P<0.01);Ⅰ-Ⅴ group breathing gradually deepened and accelerated.After 5 h,the respiration rate of Ⅲ,Ⅳ and Ⅴ were significantly higher than the control group,Ⅰ and Ⅱ group(P<0.05),but the respiratory rate of Ⅵ group was significantly lower than Ⅲ,Ⅳ and Ⅴ groups(P<0.01).In the treatment of diseases of chickens,the safe drinking water dose of Tilmicosin is 400-600 mg/L,more than 800 mg/L,has a significant impact on cardiopulmonary function.

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