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Position: Home > Articles > Comparison of Penetration Enhancer on Skin of Azone and Borneolum to Osthole Journal of Jinling Institute of Technology 2008,24 (3) 96-99

氮酮和冰片对蛇床子素的促进透皮效果比较

作  者:
戴鼎震;杜改梅;王晶;蒋加进;陈钟鸣;张志成
单  位:
金陵科技学院动物科学与技术学院
关键词:
蛇床子素;涂膜剂;透皮
摘  要:
用高效液相色谱法,以V(甲醇)∶V(水)=70∶30作为流动相,研究4种不同配方促透剂组合(5%冰片,5%氮酮,5%冰片+5%氮酮及空白对照)对复方蛇床子涂膜剂中蛇床子素对大鼠经皮渗透的促透作用,测定蛇床子素在皮肤和肌肉中的含量并进行比较分析和评价,结果表明:5%的冰片促进蛇床子素透皮效果最好。
译  名:
Comparison of Penetration Enhancer on Skin of Azone and Borneolum to Osthole
作  者:
DAI Ding-zhen1,DU Gai-mei1,WANG Jing1,2,JIANG Jia-jin1,CHEN Zhong-ming1,ZHANG Zhi-cheng1(1.Jinling Institute of Technology,Nanjing 210038,China;2.Nanjing Agricultural University,Nanjing 210095,China)
关键词:
osthole;balm;skin penetration
摘  要:
Objective:The experiment was conducted to study the effect of four different penetration enhancer combination(5% borneolum,5% azone,5% borneolum+5% azone,negative control) to osthole on rat skin penetration in compound fruetus cridii balm.Mehthods: four different penetration were compared by detecting the amount of osthole in skin and muscle of rat by HPLC,menthols/water(70/30) as liquid phase.Result: 5% borneolum achieve the best result of skin penetration of osthole.

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