Position: Home > Articles > Bioactivity of Podophyllotoxin and It's Analogues against the 3rd Instar larvae of Clostera anastomosis L.
Agrochemicals
2004,43
(9)
424-426
4种鬼臼毒素类似物对分月扇舟蛾的生物活性研究
作 者：
高蓉;狄旭东;杨振德;丛宁;田瑄;赵博光;肖杭
单 位：
南京医科大学应用毒理研究所神经毒理室;兰州大学应用有机国家重点实验室;南京林业大学森林资源与环境学院
关键词：
鬼臼毒素类似物;分月扇舟蛾;植物源杀虫剂
摘 要：
室内测定了脱氧鬼臼毒素 、β-阿朴苦鬼臼、鬼臼毒素、4-去甲鬼臼毒素4种鬼臼毒素类似物对3龄分月扇舟蛾(Clostera anastomosis L.)幼虫的拒食、毒杀、生长发育抑制活性。结果表明:(1)4种化合物对杨树分月扇舟蛾均有拒食活性,24h的拒食中浓度分别为0.217、0.508、1.109、0.895mg/ml。(2)4种化合物对分月扇舟蛾幼虫均有毒杀作用,LC50分别为0.0176、0.0028、0.3335、0.1335mg/ml。(3)4种化合物对分月扇舟蛾幼虫生长发育有抑制作用,生长发育抑制率分别为46.13%、38.23%、33.23%、21.60%,使幼虫历期延长,且生长发育抑制活性之间存在显著差异。根据毒杀、拒食、生长发育抑制的试验结果分析认为:4种鬼臼毒素类似物对分月扇舟蛾的拒食、毒杀、生长发育抑制活性之间的差异可能与结构上的差异有关。
译 名：
Bioactivity of Podophyllotoxin and It's Analogues against the 3rd Instar larvae of Clostera anastomosis L.
作 者：
GAO Rong1,DI Xu-Dong1,3,YANG Zhen-De2, CONG Ning1TIAN Xuan4, ZHAO Bo-Guang2, XIAO Hang1(1Institute of Applied Toxicology of Nanjing Medical Unixersity,Nanjing 210029,China;2College of Forest Resource and Environment,Nanjing Forestry University,Nanjing 210037,China;3Changzhou Center for Disease Control and Prevention,Changzhou 213003, China;4 State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China)
关键词：
podophyllotoxin analogues, Clostera anastomosis L, botanical insecticide
摘 要：
The bioactivities of four podophyllotoxin analogues were tested against Clostera anastomosis L. The resultsindicated that: (1) all the four analogues showed antifeedant activity, and their AFC50 were 0.217, 0.508, 1.109, 0.895mg /mlrespectively; (2) all the four analogues exhibited toxicity and their LC50 were 0.0176, 0.0028, 0.3335, 0.1335mg /ml; (3)all thefour analogues displayed inhibitory effect on growth and development and their inhibitory rate were 46.13%, 38.23%,33.23%, 21.6%. The differences among four analogues were significant. Based on the data obtained in this investigation, it ispossible that the dissimilarity in the structure of the analogues leads to their different bioactivity.
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