译 名：
Progress in the Human Granulocyte macrophage Colony stimulating Factor
作 者：
CHEN Wen chao,AI Xiao jie,QIAO Zhong dong (School of Agriculture and Biology, Shanghai Jiaotong Univ., Shanghai 201101, China)
关键词：
hGM-CSF; expression regulation; signal transduction; target cell; expression system
摘 要：
The human granulocyte-macrophage colony-stimulating factor (hGM-CSF) is an important hematopoietic cytokine. The expression of hGM-CSF gene is regulated at the transcriptional and posttranscriptional levels. hGM-CSF receptor is composed of αand βc subunits. It is involved in the Ras/Raf/MAPK and JAK/STAT pathways. hGM-CSF enhances the target cell differentiation, survival and proliferation, etc. Expression systems and clinical application of hGM-CSF were discussed.
